Bioaccumulation of selected PCBs in zebrafish, three-spined stickleback, and arctic char after three different routes of exposure

被引：53

作者：

Andersson P.L. ^{[1
,5
]}

Berg A.H. ^{[2
]}

Bjerselius R. ^{[3
]}

Norrgren L. ^{[4
]}

Olsén H. ^{[3
]}

Olsson P.-E. ^{[2
]}

Örn S. ^{[4
]}

Tysklind M. ^{[1
]}

机构：

[1] Department of Chemistry, Environmental Chemistry, Ume0å University

[2] Dept. of Cell and Molecular Biology, Division of Physiology, Umeå University

[3] Dept. of Environmental Toxicology, Uppsala University

[4] Department of Pathology, Faculty of Veterinary Medicine, Swed. Univ. of Agricultural Sciences, SE-750 07 Uppsala

[5] Research Institute of Toxicology, Utrecht University, 3508 TD Utrecht

来源：

Archives of Environmental Contamination and Toxicology | 2001年 / 40卷 / 4期

关键词：

PCBs; Biphenyl; Bioaccumulation; Arctic Char; Substitution Pattern;

D O I：

10.1007/s002440010205

中图分类号：

学科分类号：

摘要：

The uptake and elimination of 20 structurally diverse tetra- to heptachlorinated biphenyls were studied in zebrafish (Danio rerio), three-spined stickleback (Gasterosteus aculeatus), and Arctic char (Salvelinus alpinus). The polychlorinated biphenyls (PCBs) were administered to the fish through food, intraperitoneal injection of Peanut oil, or intraperitoneal implantation of silicone capsules. The retention of the PCBs in fish exposed through their diet was related with the substitution patterns of the compounds. Ortho-substituted congeners with no unsubstituted meta-para positions had high biomagnification potential. PCBs with low biomagnification all had adjacent vicinal hydrogens, indicating that congeners with this feature may have been metabolically eliminated. The retention characteristics of the PCBs in the diet-exposed and the injected zebrafish were similar. The pattern of congeners in Arctic char indicates that they have a lower capacity to metabolize PCBs compared to three-spined sticklebacks and zebrafish. The levels in the fish exposed to the PCBs through a silastic implant were negatively correlated with the hydrophobicity of the congeners. Most probably congener-specific release rates of the PCBs from the implants mask their retention characteristics. It is suggested that food, mimicking the natural intake route, should be used in PCB exposure studies to validate extrapolations to natural situations.

引用

页码：519 / 530

页数：11

共 45 条

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