A structural interpretation of the effect of GC-content on efficiency of RNA interference

[1] Fire A(1998)Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans Nature 391 806-811

[2] Xu S(2001)Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells Nature 411 494-498

[3] Montgomery MK(2002)A system for stable expression of short interfering RNAs in mammalian cells Science 296 550-553

[4] Kostas SA(2002)Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells Genes Dev 16 948-958

[5] Driver SE(2002)Positional effects of short interfering RNAs targeting the human coagulation trigger Tissue Factor Nucleic acids research 30 1757-1766

[6] Mello CC(2004)Rational siRNA design for RNA interference Nature biotechnology 22 326-330

[7] Elbashir SM(2007)Effect of target secondary structure on RNAi efficiency RNA 13 1631-1640

[8] Harborth J(2005)HIV-1 can escape from RNA interference by evolving an alternative structure in its RNA genome Nucleic acids research 33 796-804

[9] Lendeckel W(2005)siRNA target site secondary structure predictions using local stable substructures Nucleic acids research 33 e30-4424

[10] Yalcin A(2003)The activity of siRNA in mammalian cells is related to structural target accessibility: a comparison with antisense oligonucleotides Nucleic acids research 31 4417-893

[1] Fire A(1998)Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans Nature 391 806-811

[2] Xu S(2001)Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells Nature 411 494-498

[3] Montgomery MK(2002)A system for stable expression of short interfering RNAs in mammalian cells Science 296 550-553

[4] Kostas SA(2002)Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells Genes Dev 16 948-958

[5] Driver SE(2002)Positional effects of short interfering RNAs targeting the human coagulation trigger Tissue Factor Nucleic acids research 30 1757-1766

[6] Mello CC(2004)Rational siRNA design for RNA interference Nature biotechnology 22 326-330

[7] Elbashir SM(2007)Effect of target secondary structure on RNAi efficiency RNA 13 1631-1640

[8] Harborth J(2005)HIV-1 can escape from RNA interference by evolving an alternative structure in its RNA genome Nucleic acids research 33 796-804

[9] Lendeckel W(2005)siRNA target site secondary structure predictions using local stable substructures Nucleic acids research 33 e30-4424

[10] Yalcin A(2003)The activity of siRNA in mammalian cells is related to structural target accessibility: a comparison with antisense oligonucleotides Nucleic acids research 31 4417-893