Non-small cell lung cancer: Radiation therapy for locoregional recurrence after complete resection

被引：22

作者：

Tada T. ^{[1
]}

Fukuda H. ^{[2
]}

Nakagawa K. ^{[3
]}

Matsui K. ^{[4
]}

Hosono M. ^{[1
]}

Takada Y. ^{[1
]}

Inoue Y. ^{[1
]}

机构：

[1] Department of Radiology, Osaka City University, Graduate School of Medicine, Abeno-ku, Osaka 545-8585

[2] Department of Radiology, Osaka Prefectural Medical Center for Respiratory and Allergic Disease, Habikino

[3] Department of Thoracic Surgery, Osaka Prefectural Medical Center for Respiratory and Allergic Disease, Habikino

[4] Department of Thoracic Malignancy, Osaka Prefectural Medical Center for Respiratory and Allergic Disease, Habikino

来源：

International Journal of Clinical Oncology | 2005年 / 10卷 / 6期

关键词：

Non-small-cell lung cancer; Radiation therapy; Recurrence; Surgery;

D O I：

10.1007/s10147-005-0526-5

中图分类号：

学科分类号：

摘要：

Background. We investigated patterns of failure after radical radiation therapy in relation to the radiation field in patients with postsurgical locoregional recurrence of non-small cell lung cancer. Methods. Between 1992 and 2002, 31 patients with locoregional recurrence were treated with radiation therapy. At the time of radiation therapy, the sites of recurrence were the bronchial stump, the regional lymph nodes, the chest wall, and both the regional lymph nodes and the chest wall in 7, 20, 3, and 1 patient, respectively. The prescribed dose was 60 Gy in 30 fractions over 6 weeks in all patients. Results. The response rate was 87%. The overall 1-year, 2-year, and 4-year Kaplan-Meier survival rates were 61%, 30%, and 15%, respectively, and the median survival time was 14 months. Locoregional relapse with or without distant metastasis occurred in 15 patients (in-field, 7; marginal, 7; out-field, 1), and distant metastasis alone occurred in 7 patients. The sites of marginal relapse were the upper margin in two patients, the ipsilateral margin in one patient, the contralateral margin in one patient, and the lower margin in three patients, respectively (in one patient, the data for marginal relapse overlapped). In all patients with relapse on the lower margin, the mediastinal lymph nodes were dissected at the initial surgery. Conclusion. Postoperative recurrent non-small cell lung cancer showed distinctive features: the response rate was high, and the incidence of marginal relapse was also high, as in small cell lung cancer. The incidence of lower marginal relapse was high, in contrast to that in surgery-naive patients. © The Japan Society of Clinical Oncology 2005.

引用

页码：425 / 428

页数：3

共 14 条

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