Enhancement of in vitro dissolution and pharmacodynamic potential of olanzapine using solid SNEDDS

被引：23

作者：

Ahsan M.N. ^{[1
]}

Verma P.R.P. ^{[1
]}

机构：

[1] Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology (Deemed University), Mesra, Ranchi, 835215, Jharkhand

来源：

Journal of Pharmaceutical Investigation | 2018年 / 48卷 / 3期

关键词：

Behavioral study; Electron microscopy studies; Flow properties; Olanzapine; S-SNEDDS;

D O I：

10.1007/s40005-017-0308-x

中图分类号：

学科分类号：

摘要：

The present research work focused on preparing a solidified lipidic self-nanoemulsifying drug delivery system (S-SNEDDS) by adsorbing liquid SNEDDS onto the surface of inert solid adsorbent (Aerosil-200) to improve the in vitro dissolution of poorly aqueous soluble drug, olanzapine and to evaluate their pharmacodynamic (Behavioral study) activity in Swiss albino mice. The liquid SNEDDS consisted of olanzapine, Acconon E and Cremophor EL. The powder flow properties were characterized using parameters viz. angle of repose (θ), Haussner’s ratio and Carr’s index. S-SNEDDS demonstrated good flow characteristics. The solid-state characterizations of S-SNEDDS by fourier transform infrared spectroscopy, differential scanning calorimeter and powder X-ray diffraction studies confirmed the amorphous behavior of olanzapine in the S-SNEDDS. Enhanced in vitro drug release and pharmacodynamic efficacy were attained from solidified-SNEDDS in comparison to olanzapine powder signifying the immense potential offered by S-SNEDDS and it could be a better alternative for oral administration of olanzapine. © 2017, The Korean Society of Pharmaceutical Sciences and Technology.

引用

页码：269 / 278

页数：9

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