HIF-2α - a mediator of stem cell altruism?

被引：0
作者：
Eoin P Cummins
机构：
[1] School of Medicine and Medical Science,
[2] The Conway Institute,undefined
[3] University College Dublin,undefined
来源：
Stem Cell Research & Therapy | / 3卷
关键词：
Stem Cell; Teratoma; Regenerative Medicine; Human Embryonic Stem Cell; Tumor Stem Cell;
D O I：
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学科分类号：
摘要：
Human embryonic stem cells (hESCs) have been reported to confer cytoprotection in the context of tissue injury. This is somewhat counterintuitive given that microenvironmental factors such as hypoxia and oxidative stress may activate p53 and result in death and differentiation of these hESCs. In this article, we discuss a novel mechanism through which hESCs can be re-programmed (through exposure to hypoxia/oxidative stress) to transiently suppress p53, enhance 'stemness', and exist in a highly cytoprotective and undifferentiated state.
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