Serum Glutamine Synthetase Has No Value as a Diagnostic Biomarker for Alzheimer’s Disease

被引:0
作者
Yannick Vermeiren
Nathalie Le Bastard
Christopher M. Clark
Sebastiaan Engelborghs
Peter P. De Deyn
机构
[1] University of Antwerp,Laboratory of Neurochemistry and Behavior, Reference Center for Biological Markers of Memory Disorders, Institute Born
[2] University of Antwerp,Bunge
[3] Middelheim and Hoge Beuken General Hospitals (ZNA),Biobank, Institute Born
[4] Artesis University College of Antwerp,Bunge
[5] University of Antwerp,Department of Neurology and Memory Clinic
[6] University of Pennsylvania,Department of Health Care Science
来源
Neurochemical Research | 2011年 / 36卷
关键词
Alzheimer’s disease; Glutamine synthetase; Biomarkers; Serum;
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摘要
In order to test whether serum glutamine synthetase (GS) is of potential diagnostic value for Alzheimer’s disease (AD), we set up a study to compare serum GS concentrations between AD patients and control subjects. The study population (n = 165) consisted of AD patients (n = 94) and age-matched (n = 41) and age-unmatched (n = 30) control subjects. Serum GS analysis was performed by means of ELISA. No significant differences in serum GS levels were found between the AD group and age-matched controls. Age correlated positively with serum GS concentrations in AD patients and control subjects. This study suggests that serum GS levels have no diagnostic value for AD.
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页码:1858 / 1862
页数:4
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