Decreased plasma levels of soluble receptor for advanced glycation end products in mild cognitive impairment

被引：0

作者：

R. Ghidoni

L. Benussi

M. Glionna

M. Franzoni

D. Geroldi

E. Emanuele

G. Binetti

机构：

[1] IRCCS “Centro S. Giovanni di Dio-FBF”,NeuroBioGen Lab

[2] AFaR,Memory Clinic

[3] University of Pavia,Interdepartmental Center for Research in Molecular Medicine (CIRMC)

来源：

Journal of Neural Transmission | 2008年 / 115卷

关键词：

Biological marker; Plasma; Mild cognitive impairment; sRAGE; AD; Cognitive decline;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Growing evidence advanced the idea that the soluble form of the receptor for advanced glycation end-products (sRAGE) might serve as a risk marker for several disorders including Alzheimer disease. We found a reduced level of circulating sRAGE in patients with mild cognitive impairment (MCI). The reduction of sRAGE in MCI, as well as the anticipation of the disease in patients with the lowest sRAGE levels (≤225 pg/ml), suggest a role of the RAGE axis in the pathogenesis of the disease.

引用

页码：1047 / 1050

页数：3

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