Further observations on the relationship between the FGFR4 Gly388Arg polymorphism and lung cancer prognosis

被引：0
作者：
A Matakidou
R el Galta
M F Rudd
E L Webb
H Bridle
T Eisen
R S Houlston
机构：
[1] Section of Cancer Genetics,Department of Oncology
[2] Institute of Cancer Research,undefined
[3] University of Cambridge,undefined
来源：
British Journal of Cancer | 2007年 / 96卷
关键词：
lung cancer; FGFR4; Gly388Arg polymorphism; prognosis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The Gly388Arg polymorphism in the fibroblast growth factor receptor 4 (FGFR4) gene has been reported to influence prognosis in a wide variety of cancer types. To determine whether Gly388Arg is a marker for lung cancer prognosis, we genotyped 619 lung cancer patients with incident disease and examined the relationship between genotype and overall survival. While we employed a comprehensive set of statistical tests, including those sensitive to the detection of differences in early survival, our data provide little evidence to support the tenet that the FGFR4 Gly388Arg polymorphism is a clinically useful marker for lung cancer prognosis.
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页码：1904 / 1907
页数：3
相关论文
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[1]  
Bange J(2002)Cancer progression and tumor cell motility are associated with the FGFR4 Arg(388) allele Cancer Res 62 840-847
[2]  
Prechtl D(2003)Allelic imbalance at loci containing FGFR, FGF, c-Met and HGF candidate genes in non-small cell lung cancer sub-types, implication for progression Eur J Cancer 39 2538-2547
[3]  
Cheburkin Y(2003)The fibroblast growth factor receptor gene Arg388 allele is not associated with early lymph node metastasis of breast cancer Cancer Epidemiol Biomarkers Prev 12 582-583
[4]  
Specht K(2001)N-CAM modulates tumour-cell adhesion to matrix by inducing FGF-receptor signalling Nat Cell Biol 3 650-657
[5]  
Harbeck N(2002)Targeted expression of a human pituitary tumor-derived isoform of FGF receptor-4 recapitulates pituitary tumorigenesis J Clin Invest 109 69-78
[6]  
Schmitt M(2004)G388R mutation of the FGFR4 gene is not relevant to breast cancer prognosis Br J Cancer 90 189-193
[7]  
Knyazeva T(2005)Case–control study of familial lung cancer risks in UK women Int J Cancer 116 445-450
[8]  
Muller S(2003)Single nucleotide polymorphism in fibroblast growth factor receptor 4 at codon 388 is associated with prognosis in high-grade soft tissue sarcoma Cancer 98 2245-2250
[9]  
Gartner S(2004)Phenotypic differences of proliferating fibroblasts in the stroma of lung adenocarcinoma and normal bronchus tissue Cancer Sci 95 226-232
[10]  
Sures I(1998)Fibroblast growth factor receptor 4, implicated in progression of islet cell carcinogenesis by its expression profile, does not contribute functionally Cell Growth Differ 9 557-564
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