A versatile liposome/cyclodextrin supramolecular carrier for drug delivery through the blood-brain barrier

被引：1
作者：
Cécile Machut-Binkowski
Frédéric Hapiot
Roméo Cecchelli
Patrick Martin
Eric Monflier
机构：
[1] Université d’Artois,Laboratoire de Physico
[2] Université d’Artois,Chimie des Interfaces et Applications, FRE CNRS 2485, Fédération Chevreul FR CNRS 2638, Faculté des Sciences Jean Perrin
来源：
Journal of Inclusion Phenomena and Macrocyclic Chemistry | 2007年 / 57卷
关键词：
Blood-brain-barrier; Cyclodextrin; Drug delivery; In vitro model; Liposome; Saccharide; Supramolecular chemistry;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
For many commercial drugs, reaching the central nervous system in large amount without damaging the blood-brain-barrier (BBB) remains a challenging task. We present here a supramolecular strategy aiming at using a well-defined cyclodextrin-coated liposomes as drug carrier and adamantoyl saccharides as BBB-interacting ligands. In this study, the liposome is constituted of n-alkyldimethylammoniumcyclodextrins incorporated in the lipid bilayer of a 3/7 cholesterol/dipalmitoylphosphatidylcholine mixture and the ligand is constituted of an adamantoylglucose molecule whose adamantoyl moiety can be included in the CD cavity. The whole supramolecular assembly has been characterized by light-scattering and 31P NMR measurements. Toxicity and permeability studies on an in vitro model of the BBB clearly demonstrated a 5-fold improved ability of the modified liposome to enter the BBB-endothelial cells compared to the non-coated liposome. Fluorescence labelling of these liposomes is also displayed with DiI as a fluorescent probe.
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页码：567 / 572
页数：5
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