AMP-activated protein kinase is activated in adipose tissue of individuals with type 2 diabetes treated with metformin: a randomised glycaemia-controlled crossover study

被引:0
作者
J. G. Boyle
P. J. Logan
G. C. Jones
M. Small
N. Sattar
J. M. C. Connell
S. J. Cleland
I. P. Salt
机构
[1] University of Glasgow,Institute of Cardiovascular and Medical Sciences, College of Medicine, Veterinary and Life Sciences, Davidson Building
[2] Gartnavel General Hospital,Department of Diabetes
[3] University of Dundee,Ninewells Hospital and Medical School
来源
Diabetologia | 2011年 / 54卷
关键词
Adipose; AMP-activated protein kinase; Biguanide; Diabetes; Glucose transport; Insulin; Metformin;
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学科分类号
摘要
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页码:1799 / 1809
页数:10
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  • [31] Souza SC(2003)Role of adiponectin in matching of fetal and placental weight in mothers with type 1 diabetes Diabetes 52 1355-1363
  • [32] Villena JA(2003)Pachymic acid stimulates glucose uptake through enhanced GLUT4 expression and translocation Diabetes 52 667-674
  • [33] Viollet B(2006)Involvement of AMP-activated protein kinase in glucose uptake stimulated by the globular domain of adiponectin in primary rat adipocytes Curr Med Res Opin 22 1921-1926
  • [34] Andreelli F(2005)Modulation of circulating and adipose tissue adiponectin levels by antidiabetic therapy Eur J Pharmacol 518 90-95
  • [35] Kahn A(2010)Effect of gliclazide modified release of adiponectin, interleukin-6, and tumor necrosis factor-alpha plasma levels in individuals with type 2 diabetes mellitus Diabetologia 53 768-778
  • [36] Vaulont S(2008)Metformin reduces adiponectin protein expression and release in 3T3-L1 adipocytes involving activation of AMP activated protein kinase J Clin Pharmacol 48 696-707
  • [37] Sul HS(2006)Biguanides and thiazolidinediones inhibit stimulated lipolysis in human adipocytes through activation of AMP-activated protein kinase J Lipid Res 47 2444-2450
  • [38] Habinowski SA(2002)Population exposure-response modeling of metformin in patients with type 2 diabetes mellitus Diabetes 51 30-36
  • [39] Witters LA(1998)The lipogenic enzymes DGAT1, FAS, and LPL in adipose tissue: effects of obesity, insulin resistance, and TZD treatment Diabetes Care 21 1301-1305
  • [40] Salt IP(2005)Regulation of glucose transport and insulin signaling by troglitazone or metformin in adipose tissue of type 2 diabetic subjects Diab Obes Metab 7 381-389