Clear cell pleomorphic xanthoastrocytoma: Case report

被引：0

作者：

Primavera J. ^{[2
,3
]}

Nikas D.C. ^{[4
]}

Zamani A.A. ^{[4
]}

Shafman T. ^{[5
]}

Alexander E. ^{[4
]}

De Girolami U. ^{[1
]}

Louis D.N. ^{[2
,3
]}

机构：

[1] Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115

[2] Department of Pathology and Neurosurgical Service, Massachusetts General Hospital, Boston, MA

[3] Harvard Medical School, Boston, MA

[4] Neurosurgical Laboratories, Brigham and Women's Hospital, Dana Farber Cancer Institute, Boston, MA

[5] Radiation Oncology, Duke University Medical Center, Durham, NC

来源：

Acta Neuropathologica | 2001年 / 102卷 / 4期

关键词：

Astrocytoma; Diagnosis; Glioma; Pleomorphic xanthoastrocytoma;

D O I：

10.1007/s004010100380

中图分类号：

学科分类号：

摘要：

Pleomorphic xanthoastrocytoma (PXA) is a well-described astrocytic neoplasm with distinctive clinical and pathological features. Although most patients with PXAs are cured by surgical excision, other patients experience malignant progression and tumor recurrence. We describe a 47-year-old woman with a left temporal lobe PXA that had classic histopathological characteristics as well as extensive clear cell and focal papillary changes, and some anaplastic findings. The patient has now suffered two recurrences after complete resection. The case illustrates a rare, previously undescribed histological variant of PXA, with a prominent clear cell and focal papillary morphology. The study of histologically similar cases is needed to determine whether this variant is always associated with a greater likelihood of recurrence.

引用

页码：404 / 408

页数：4

共 20 条

[1] Bucciero A., De Caro M.I., Tedeschi E., De Stefano V., Bianco M., Soricelli A., Vizioli L., Cerillo A., Atypical pleomorphic xanthoastrocytoma, J Neurosurg Sci, 42, pp. 153-157, (1998)
[2] Cervoni L., Salvati M., Santoro A., Celli P., Pleomorphic xanthoastrocytoma: Some observations, Neurosurg Rev, 19, pp. 13-16, (1996)
[3] Davies K.G., Maxwell R.E., Seljeskog E., Sung J.H., Pleomorphic xanthoastrocytoma - Report of four cases, with MRI scan appearances and literature review, Br J Neurosurg, 8, pp. 681-689, (1994)
[4] Giannini C., Scheithauer B.W., Burger P.C., Brat D.J., Wollan P.C., Lach B., O'Neill B.P., Pleomorphic xanthoastrocytoma: What do we really know about it?, Cancer, 85, pp. 2033-2045, (1999)
[5] Gokden M., Roth K.A., Carroll S.L., Wick M.R., Schmidt R.E., Clear cell neoplasms and pseudoneoplastic lesions of the central nervous system, Semin Diagn Pathol, 14, pp. 253-269, (1997)
[6] Kepes J.J., Astrocytomas: Old and newly recognized variants, their spectrum of morphology and antigen expression, Can J Neurol Sci, 14, pp. 109-121, (1987)
[7] Kepes J.J., Pleomorphic xanthoastrocytoma: The birth of a diagnosis and concept, Brain Pathol, 3, pp. 269-274, (1993)
[8] Kepes J.J., Rubinstein L.J., Malignant gliomas with heavily lipidized (foamy) tumor cells, Cancer, 47, pp. 2451-2459, (1981)
[9] Kepes J.J., Rubinstein L.J., Eng L.F., Pleomorphic xanthoastrocytoma: A distinctive meningocerebral glioma of young subjects with a relatively favorable prognosis, Cancer, 44, pp. 1839-1852, (1979)
[10] Kepes J.J., Rubinstein L.J., Ansbacher L., Schreiber D.J., Histopathological features of recurrent pleomorphic xanthoastrocytoma: Further corroboration of the glial nature of this neoplasm, Acta Neuropathol, 78, pp. 585-593, (1989)

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