Genetic characterization of H1N1, H1N2 and H3N2 swine influenza virus in Thailand

被引：0
作者：
Salin Chutinimitkul
Nattakarn Thippamom
Sudarat Damrongwatanapokin
Sunchai Payungporn
Roongroje Thanawongnuwech
Alongkorn Amonsin
Pitirat Boonsuk
Donruethai Sreta
Napawan Bunpong
Rachod Tantilertcharoen
Pornchai Chamnanpood
Sujira Parchariyanon
Apiradee Theamboonlers
Yong Poovorawan
机构：
[1] Chulalongkorn University,Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine
[2] Chulalongkorn University,Faculty of Veterinary Science
[3] National Institute of Animal Health,Department of Livestock Development
来源：
Archives of Virology | 2008年 / 153卷
关键词：
Influenza Virus; H1N1 Virus; Avian Influenza Virus; Antigenic Site; Swine Influenza Virus;
D O I：
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摘要：
Swine have been known to be a suitable host for influenza A virus. In Thailand, phylogenetic analysis on swine influenza virus (SIV) has as yet not been attempted. The present report presents molecular and phylogenetic analysis performed on SIV in Thailand. In this study, 12 SIV isolates from the central and eastern part of Thailand were subtyped and the molecular genetics of hemagglutinin and neuraminidase were elucidated. Three subtypes, H1N1, H1N2 and H3N2, are described. Phylogenetic analysis of the SIV hemagglutinin and neuraminidase genes shows individual clusters with swine, human or avian influenza virus at various global locations. Furthermore, amino acid substitutions were detected either at the receptor binding site or the antigenic sites of the hemagglutinin gene.
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