Dynamic interplay between locus-specific DNA methylation and hydroxymethylation regulates distinct biological pathways in prostate carcinogenesis

被引:0
作者
Shivani N. Kamdar
Linh T. Ho
Ken J. Kron
Ruth Isserlin
Theodorus van der Kwast
Alexandre R. Zlotta
Neil E. Fleshner
Gary Bader
Bharati Bapat
机构
[1] University of Toronto,Department of Laboratory Medicine and Pathobiology
[2] Lunenfeld-Tanenbaum Research Institute,Mount Sinai Hospital
[3] University of Toronto,The Donnelly Centre for Cellular and Biomolecular Research
[4] University of Toronto,Department of Pathology, University Health Network
[5] University of Toronto,Department of Surgery and Surgical Oncology, Division of Urology, University Health Network
[6] University Health Network,Division of Urology
来源
Clinical Epigenetics | 2016年 / 8卷
关键词
5-Hydroxymethylcytosine; 5-Methylcytosine; Whole-genome; Prostate cancer; Cell lines; Integrative analysis;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 145 条
[1]  
Van Vlodrop IJ(2011)Analysis of promoter CpG island hypermethylation in cancer: location, location, location! Clin Cancer Res 21 5427-5440
[2]  
Niessen HE(2002)CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future Oncogene 196 1-7
[3]  
Derks S(2012)Tissue of origin determines cancer-associated CpG island promoter hypermethylation patterns Genome Biol 460 231-234
[4]  
Baldewijns MM(2002)Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours J Pathol 104 347-351
[5]  
van Criekinge W(1999)DNA methylation and chromosome instability in breast cancer cell lines FEBS Lett 2 627-637
[6]  
Herman JG(2014)From development to diseases: the role of 5hmC in brain Genomics 564 109-118
[7]  
Esteller M(2011)Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers Oncotarget 22 467-477
[8]  
Sproul D(2015)Hydroxymethylation and its potential implication in DNA repair system: a review and future perspectives Gene 40 8255-8265
[9]  
Kitchen RR(2012)Tissue type is a major modifier of the 5-hydroxymethylcytosine content of human genes Genome Res 111 11139-11144
[10]  
Nestor CE(2012)Dynamic hydroxymethylation of deoxyribonucleic acid marks differentiation-associated enhancers Nucleic Acids Res 39 131-137