Numerous cellular processes require the concerted action of multiple proteins that assemble in functional complexes. Protein-protein interaction domains allow specific proteins to combine with certain partners. Specificity of protein-protein association can be obtained by an interaction code predicted by conserved amino acid sequences. One of the protein-protein interaction motifs is the LIM domain, a conserved cysteine-rich module present in more than 100 different human proteins. The human four-and-a-half-LIM-only protein family consists of the members FHL1, FHL2, FHL3, FHL4 and ACT. They are expressed in a cell- and tissue-specific manner and participate in various cellular processes, including regulation of cell survival, transcription and signal transduction. Here, we review the current knowledge of the best-studied member of this family, FHL2. We describe the transcription regulation, the expression profile, the interaction partners, the subcellular localization, the biological functions and discuss the possible involvement of FHL2 in human diseases.
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Institute of Pathology, University of Cologne, Cologne
Gerhard-Domagk-Institute of Pathology, University of Münster, MünsterInstitute of Pathology, University of Cologne, Cologne
Huss S.
Stellmacher C.
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Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital Aachen, AachenInstitute of Pathology, University of Cologne, Cologne
Stellmacher C.
Goltz D.
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Institute of Pathology, University of Bonn, BonnInstitute of Pathology, University of Cologne, Cologne
Goltz D.
Khlistunova I.
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Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital Aachen, AachenInstitute of Pathology, University of Cologne, Cologne
Khlistunova I.
Adam A.C.
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Institute of Pathology, University of Cologne, CologneInstitute of Pathology, University of Cologne, Cologne
Adam A.C.
Trebicka J.
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Department of Internal Medicine I, University of Bonn, BonnInstitute of Pathology, University of Cologne, Cologne
Trebicka J.
Kirfel J.
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Institute of Pathology, University of Bonn, BonnInstitute of Pathology, University of Cologne, Cologne
Kirfel J.
Büttner R.
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Institute of Pathology, University of Cologne, CologneInstitute of Pathology, University of Cologne, Cologne
Büttner R.
Weiskirchen R.
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Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital Aachen, AachenInstitute of Pathology, University of Cologne, Cologne
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Hebei Agr Univ, Coll Anim Sci & Technol, Baoding 071000, Peoples R China
Zhengzhou Normal Univ, Lab Mol Biol, Zhengzhou, Peoples R ChinaHebei Agr Univ, Coll Anim Sci & Technol, Baoding 071000, Peoples R China
Zhang, Limeng
Li, Runting
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Hebei Agr Univ, Coll Anim Sci & Technol, Baoding 071000, Peoples R China
Zhengzhou Normal Univ, Lab Mol Biol, Zhengzhou, Peoples R ChinaHebei Agr Univ, Coll Anim Sci & Technol, Baoding 071000, Peoples R China
Li, Runting
Chen, Longxin
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Zhengzhou Normal Univ, Lab Mol Biol, Zhengzhou, Peoples R ChinaHebei Agr Univ, Coll Anim Sci & Technol, Baoding 071000, Peoples R China
Chen, Longxin
Xing, Zhenzhen
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Zhengzhou Normal Univ, Lab Mol Biol, Zhengzhou, Peoples R ChinaHebei Agr Univ, Coll Anim Sci & Technol, Baoding 071000, Peoples R China
Xing, Zhenzhen
Song, Yue
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Zhengzhou Normal Univ, Lab Mol Biol, Zhengzhou, Peoples R ChinaHebei Agr Univ, Coll Anim Sci & Technol, Baoding 071000, Peoples R China
Song, Yue
Nie, Xiaoning
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Zhengzhou Normal Univ, Lab Mol Biol, Zhengzhou, Peoples R ChinaHebei Agr Univ, Coll Anim Sci & Technol, Baoding 071000, Peoples R China
Nie, Xiaoning
Wang, Linqing
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Zhengzhou Normal Univ, Lab Mol Biol, Zhengzhou, Peoples R ChinaHebei Agr Univ, Coll Anim Sci & Technol, Baoding 071000, Peoples R China
Wang, Linqing
Han, Hongye
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Hebei Agr Univ, Coll Anim Sci & Technol, Baoding 071000, Peoples R ChinaHebei Agr Univ, Coll Anim Sci & Technol, Baoding 071000, Peoples R China
Han, Hongye
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Liu, Aiju
Ma, Xiaofei
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Hebei Agr Univ, Coll Anim Sci & Technol, Baoding 071000, Peoples R ChinaHebei Agr Univ, Coll Anim Sci & Technol, Baoding 071000, Peoples R China
Ma, Xiaofei
Ma, Runlin Z.
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Zhengzhou Normal Univ, Lab Mol Biol, Zhengzhou, Peoples R China
Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol Dev Biol, Beijing, Peoples R ChinaHebei Agr Univ, Coll Anim Sci & Technol, Baoding 071000, Peoples R China
Ma, Runlin Z.
Tian, Shujun
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Hebei Agr Univ, Coll Anim Sci & Technol, Baoding 071000, Peoples R China
Embryon Tech Hebei Prov, Res Ctr Cattle & Sheep, Baoding, Peoples R ChinaHebei Agr Univ, Coll Anim Sci & Technol, Baoding 071000, Peoples R China