Immunity and Hepatitis C: A Review

被引：0
作者：
Rebecca R. Terilli
Andrea L. Cox
机构：
[1] Johns Hopkins University School of Medicine,Division of Infectious Diseases
来源：
Current HIV/AIDS Reports | 2013年 / 10卷
关键词：
Hepatitis C; HCV; Viral hepatitis; Hepatitis; Immunity; Innate immune response; Interferons; IFN; Cellular immunity; Adaptive immune response; Neutralizing antibodies; Chronic infection; Acute infection; Liver disease; Spontaneous clearance; Treatment response; SVR; Vaccination; HIV; HIV-HCV coinfection; Coinfection; T cell response; B cell response; Interleukin 18; Interleukin 28B; Virus;
D O I：
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中图分类号：
学科分类号：
摘要：
Hepatitis C virus (HCV) is a major cause of chronic hepatitis and hepatocellular carcinoma worldwide. Due to shared transmission routes, the prevalence of HCV is especially high among individuals infected with HIV. HIV uninfected individuals spontaneously clear HCV approximately 30 % of the time, while the rate of control in HIV infected individuals who subsequently acquire HCV is substantially lower. In addition, complications of HCV are more frequent in those with HIV infection, making liver disease the leading cause of non-AIDS-related death in HIV infected individuals. This review summarizes recent advances in understanding the role of the innate and adaptive immune responses to HCV in those with and without HIV. Further defining the interaction between hepatitis C and the host immune system will potentially reveal insights into HCV pathogenesis and the host’s ability to prevent persistent infection, as well as direct the development of vaccines.
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页码：51 / 58
页数：7
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