Aspirin vs Heparin for the Prevention of Preeclampsia

被引：0
作者：
Vasiliki Katsi
Theoni Kanellopoulou
Thomas Makris
Petros Nihoyannopoulos
Efrosyni Nomikou
Dimitrios Tousoulis
机构：
[1] Hippokration Hospital,Department of Cardiology
[2] Hippokration Hospital,Blood Bank and Hemophilia Unit
[3] Helena Venizelou Hospital,Department of Cardiology
[4] Athens University Medical School,First Cardiology Department
[5] Hippokration Hospital,undefined
来源：
Current Hypertension Reports | 2016年 / 18卷
关键词：
Preeclampsia; Hypertension; Placental disease; Pregnancy complications; Aspirin; Heparin;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Preeclampsia is a hypertensive disorder of pregnancy that remains a significant cause of maternal morbidity and mortality worldwide. Preeclampsia can be resolved by delivery, and most of the proposed preventive treatment approaches are based on processes involved in placental development in early pregnancy. Yet, none of these has been established in clinical practice. Low-dose aspirin is the most promising candidate, nevertheless; while some individual randomized controlled trials showed minimal or no statistically significant benefit, recent metanalyses showed that early initiation before 16 weeks of gestation is associated with prevention of early-onset preeclampsia and reduction in prevalence of perinatal death or morbidity of pregnant women. Heparin could be an alternative antithrombotic and anti-inflammatory median to prevent preeclampsia either alone or in combination with aspirin; however, results are conflicting concerning efficacy.
引用
收藏
相关论文
共 263 条
  • [1] Myatt L(2015)Preeclampsia: syndrome or disease? Curr Hypertens Rep 17 83-3
  • [2] Roberts JM(2011)Hypertensive disorders during pregnancy: clinical applicability of risk prediction models J Hypertens 29 2320-80
  • [3] Angeli F(2005)The pre-eclampsia community guideline (PRECOG): how to screen for and detect onset of pre-eclampsia in the community BMJ 330 576-6
  • [4] Angeli E(2012)VTE, thrombophilia, antithrombotic therapy, and pregnancy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines Chest 141 351-3
  • [5] Reboldi G(1989)The use of aspirin to prevent pregnancy-induced hypertension and lower the ratio of thromboxane A2 to prostacyclin in relatively high risk pregnancies N Engl J Med 321 1-2
  • [6] Verdecchia P(1986)Low-dose aspirin prevents pregnancy-induced hypertension and pre-eclampsia in angiotensin-sensitive primigravidae Lancet 1 840-5
  • [7] Milne F(1985)Prevention of pre-eclampsia by early antiplatelet therapy Lancet 1 1552-8
  • [8] Redman C(1990)Doppler ultrasound and aspirin in recognition and prevention of pregnancy-induced hypertension Lancet 335 1213-9
  • [9] Walker J(1993)Prevention of preeclampsia with low-dose aspirin in healthy, nulliparous pregnant women. The National Institute of Child Health and Human Development Network of Maternal Fetal Medicine Units N Engl J Med 329 625-8
  • [10] Baker P(1996)Prediction of pre-eclampsia by abnormal uterine Doppler ultrasound and modification by aspirin Br J Obstet Gynaecol 103 13-7
12345678910