Quality of life in patients with food allergy

被引：83
作者：
Antolín-Amérigo D. [1 ]
Manso L. [2 ]
Caminati M. [3 ]
de la Hoz Caballer B. [4 ]
Cerecedo I. [5 ]
Muriel A. [6 ]
Rodríguez-Rodríguez M. [1 ]
Barbarroja-Escudero J. [1 ]
Sánchez-González M.J. [1 ]
Huertas-Barbudo B. [2 ]
Alvarez-Mon M. [1 ]
机构：
[1] Universidad de Alcalá, Hospital Universitario Principe de Asturias, Departamento de Medicina y Especialidades Médicas, Carretera de Alcalá-Meco s/n, Alcalá de Henares, Madrid
[2] Unidad de Alergia, Hospital del Sureste. Arganda del Rey, Madrid
[3] Verona University and General Hospital, Allergy Unit, Verona
[4] Hospital Universitario Ramón y Cajal, IRYCIS, Servicio de Alergia, Madrid
[5] Hospital Universitario Clínico San Carlos, Servicio de Alergia, Madrid
[6] Hospital Universitario Ramón y Cajal, IRYCIS, Unidad de Bioestadística Clínica, Madrid
来源：
Clinical and Molecular Allergy | / 14卷 / 1期
关键词：
Anaphylaxis; Food allergy; Health-related quality of life (HRQL); Quality of life; Questionnaire; Specific questionnaire;
D O I：
10.1186/s12948-016-0041-4
中图分类号：
学科分类号：
摘要：
Food allergy has increased in developed countries and can have a dramatic effect on quality of life, so as to provoke fatal reactions. We aimed to outline the socioeconomic impact that food allergy exerts in this kind of patients by performing a complete review of the literature and also describing the factors that may influence, to a greater extent, the quality of life of patients with food allergy and analyzing the different questionnaires available. Hitherto, strict avoidance of the culprit food(s) and use of emergency medications are the pillars to manage this condition. Promising approaches such as specific oral or epicutaneous immunotherapy and the use of monoclonal antibodies are progressively being investigated worldwide. However, even that an increasing number of centers fulfill those approaches, they are not fully implemented enough in clinical practice. The mean annual cost of health care has been estimated in international dollars (I$) 2016 for food-allergic adults and I$1089 for controls, a difference of I$927 (95 % confidence interval I$324-I$1530). A similar result was found for adults in each country, and for children, and interestingly, it was not sensitive to baseline demographic differences. Cost was significantly related to severity of illness in cases in nine countries. The constant threat of exposure, need for vigilance and expectation of outcome can have a tremendous impact on quality of life. Several studies have analyzed the impact of food allergy on health-related quality of life (HRQL) in adults and children in different countries. There have been described different factors that could modify HRQL in food allergic patients, the most important of them are perceived disease severity, age of the patient, peanut or soy allergy, country of origin and having allergy to two or more foods. Over the last few years, several different specific Quality of Life questionnaires for food allergic patients have been developed and translated to different languages and cultures. It is important to perform lingual and cultural translations of existent questionnaires in order to ensure its suitability in a specific region or country with its own socioeconomic reality and culture. Tools aimed at assessing the impact of food allergy on HRQL should be always part of the diagnostic work up, in order to provide a complete basal assessment, to highlight target of intervention as well as to evaluate the effectiveness of interventions designed to cure food allergy. HRQL may be the only meaningful outcome measure available for food allergy measuring this continuous burden. © 2016 Antolín-Amérigo et al.
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共 60 条
[1]  
Vieths S., Reese G., Ballmer-Weber B.K., Beyer K., Burney P., Fernandez-Rivas M., Et al., The serum bank of EuroPrevall-the prevalence, cost and basis of food allergy across Europe, Food Chem Toxicol, 46, pp. 12-14, (2008)
[2]  
Muraro A., Roberts G., Worm M., Bilo M.B., Brockow K., Fernandez Rivas M., Santos A.F., Zolkipli Z.Q., Bellou A., Beyer K., Bindslev-Jensen C., Cardona V., Clark A.T., Demoly P., Dubois A.E., DunnGalvin A., Eigenmann P., Halken S., Harada L., Lack G., Jutel M., Niggemann B., Rueff F., Timmermans F., Vlieg-Boerstra B.J., Werfel T., Dhami S., Panesar S., Akdis C.A., Sheikh A., Anaphylaxis: guidelines from the European academy of allergy and clinical immunology, Allergy, 69, pp. 1026-1045, (2014)
[3]  
Sicherer S.H., Epidemiology of food allergy, J Allergy Clin Immunol, 127, pp. 594-602, (2011)
[4]  
Ben-Shoshan M., Turnbull E., Clarke A., Food allergy: temporal trends and determinants, Curr Allergy Asthma Rep, 12, pp. 346-372, (2012)
[5]  
Fernandez Rivas M., Food allergy in alergologica-2005, J Investig Allergol Clin Immunol, 19, pp. 37-44, (2009)
[6]  
Barnett J., Leftwich J., Muncer K., Grimshaw K., Shepherd R., Raats M.M., Et al., How do peanut and nut-allergic consumers use information on the packaging to avoid allergens?, Allergy, 66, pp. 969-978, (2011)
[7]  
Goossens N.J., Flokstra-de Blok B.M., Meulen G.N., Arnlind M.H., Asero R., Barreales L., Et al., Health-related quality of life in food-allergic adults from eight European countries, Ann Allergy Asthma Immunol, 113, 63-68, (2014)
[8]  
Blok B.M., Vlieg-Boerstra B.J., Oude Elberink J.N., Duiverman E.J., DunnGalvin A., Hourihane J.O., Et al., A framework for measuring the social impact of food allergy across Europe: a EuroPrevall state of the art paper, Allergy, 62, pp. 733-737, (2007)
[9]  
Flokstra-de Blok B.M.J., Velde J.L., Vlieg-Boerstra B.J., Oude Elberink J.N.G., DunnGalvin A., Hourihane J.O., Et al., Health-related quality of life of food allergic patients measured with generic and disease-specific questionnaires, Allergy, 65, pp. 1031-1038, (2010)
[10]  
Flokstra-de Blok B.M.J., Dubois A.E.J., Vlieg-Boerstra B.J., Oude Elberink N.G., Raat H., DunnGalvin A., Et al., Health-related quality of life of food allergic patients: comparison with the general population and other diseases, Allergy, 65, pp. 238-244, (2010)
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