Central nervous system vasculitis in children

被引：33
作者：
Benseler S.M. [1 ]
机构：
[1] Division of Pediatric Emergency Medicine and Rheumatology, Research Institute, Hospital for Sick Children, Toronto, Ont. M5G 1X8
来源：
Current Rheumatology Reports | 2006年 / 8卷 / 6期
关键词：
Vasculitis; Magnetic Resonance Angiography; Moyamoya Disease; Conventional Angiography; Brain Biopsy;
D O I：
10.1007/s11926-006-0040-4
中图分类号：
学科分类号：
摘要：
Central nervous system (CNS) vasculitis is an increasingly recognized, often devastating inflammatory brain disease of children and adults. In primary or isolated CNS vasculitis/angiitis of childhood (cPACNS), the vascular inflammation is limited to the brain and spinal cord. Secondary CNS vasculitis occurs in a variety of conditions including infections, collagen vascular diseases, systemic vasculidities, and malignancies. Mimics of CNS vasculitis in children include dissections and noninflammatory vasculopathies. Diagnosis of primary CNS vasculitis in both adults and children is based on the Calabrese criteria. This review summarizes recent data on CNS vasculitis in children; reviews the clinical spectrum at presentation and the role of laboratory tests, neuroimaging, and brain biopsy; and discusses treatment strategies, outcome data, and overlapping conditions of cPACNS. Copyright © 2006 by Current Science Inc.
引用
收藏
页码：442 / 449
页数：7
相关论文
共 56 条
[1]  
Gallagher K.T., Shaham B., Reiff A., Et al., Primary angiitis of the central nervous system in children: 5 cases, J Rheumatol, 28, pp. 616-623, (2001)
[2]  
Lanthier S., Lortie A., Michaud J., Et al., Isolated angiitis of the CNS in children, Neurology, 56, pp. 837-842, (2001)
[3]  
Benseler S., Schneider R., Central nervous system vasculitis in children, Curr Opin Rheumatol, 16, pp. 43-50, (2004)
[4]  
Patsalides A.D., Wood L.V., Atac G.K., Et al., Cerebrovascular disease in HIV-infected pediatric patients: Neuroimaging findings, AJR Am J Roentgenol, 179, pp. 999-1003, (2002)
[5]  
Ueno M., Oka A., Koeda T., Et al., Unilateral occlusion of the middle cerebral artery after varicella-zoster virus infection, Brain Dev, 24, pp. 106-108, (2002)
[6]  
Lloyd-Still J.D., Tomasi L., Neurovascular and thromboembolic complications of inflammatory bowel disease in childhood, J Pediatr Gastroenteral Nutr, 9, pp. 461-466, (1989)
[7]  
von Scheven E., Lee C., Berg B.O., Pediatric Wegener's granulomatosis complicated by central nervous system vasculitis, Pediatr Neurol, 19, pp. 317-319, (1998)
[8]  
Deshpande P.V., Gilbert R., Alton H., Milford D.V., Microscopic polyarteritis with renal and cerebral involvement, Pediatr Nephrol, 15, pp. 134-135, (2000)
[9]  
Nadeau S.E., Neurologic manifestations of systemic vasculitis, Neurol Clin, 20, pp. 123-150, (2002)
[10]  
Belostotsky V.M., Shah V., Dillon M.J., Clinical features in 17 paediatric patients with Wegener granulomatosis, Pediatr Nephrol, 17, pp. 754-761, (2002)
123456