Assessment of cytotoxicity and oxidative stress induced by titanium oxide nanoparticles on Chinook salmon cells

被引：0
|
作者：
Koigoora Srikanth
Eduarda Pereira
Armando C Duarte
Iqbal Ahmad
Janapala Venkateswara Rao
机构：
[1] University of Aveiro,CESAM
[2] Indian Institute of Chemical Technology,Centre for Environmental and Marine Studies & Department of Chemistry
来源：
Environmental Science and Pollution Research | 2015年 / 22卷
关键词：
Chinook salmon; Titanium oxide nanoparticles; Cytotoxicity; Oxidative stress; Lipid peroxidation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Titanium oxide nanoparticles (TiO2 NPs) have received wide attention in diverse application, but the potential impact of these nanomaterials on the environment, aquatic life and especially on fish cell lines is lacking. The present study aimed to investigate the cytotoxicity and oxidative stress induced by TiO2 NPs on Chinook salmon cells derived from Oncorhynchus tshawytscha embryos (CHSE-214). The The MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide] and neutral red (NR) assays in CHSE-214 cells exposed to TiO2 NPs revealed concentration-dependent cytotoxic effect in the range of 10 to 60 μg/ml for 24 h. CHSE-214 cells exposed to TiO2 NPs (10-60 μg/ml) exhibited significant decline in superoxide dismutase (SOD), catalase (CAT) glutathione (GSH) content and increased lipid peroxidation (LPO) in a concentration-dependent manner. TiO2 NPs induced cytotoxicity and oxidative stress in CHSE-214 cells which serve as a base line studies for future studies.
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页码：15571 / 15578
页数：7
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