Dopamine D4 receptor polymorphism and idiopathic Parkinson's disease

被引：0

作者：

Martina F Kronenberg

Hans-Jürgen Menzel

Georg Ebersbach

Gregor K Wenning

Elisabeth Luginger

Martin Gollner

Gerhard Ransmayr

Gerd Utermann

Werner Poewe

Florian Kronenberg

机构：

[1] Innsbruck University Hospital,Department of Neurology

[2] Institute of Medical Biology and Human Genetics,undefined

[3] University of Innsbruck,undefined

来源：

European Journal of Human Genetics | 1999年 / 7卷

关键词：

Parkinson's disease; dopamine receptor; dopamine D4 receptor; polymorphism; susceptibility gene; association study; novelty seeking;

D O I：

暂无

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学科分类号：

摘要：

Patients with idiopathic Parkinson's disease (IPD) are described as having markedly decreased novelty seeking characteristics. Since recent publications suggest an association between the dopamine D4 receptor polymorphism and novelty seeking, we investigated this polymorphism in a group of 122 patients with IPD and 127 healthy control subjects. We found similar allele and genotype frequencies in both groups and no association with the age of onset of symptoms. Therefore, the dopamine D4 receptor polymorphism does not confer genetic susceptibility to IPD and cannot explain the decreased novelty seeking in IPD patients.

引用

页码：397 / 400

页数：3