Diagnostic accuracy of 64-slice computed tomography coronary angiography in patients with low-to-intermediate risk

被引：47

作者：

Cademartiri F. ^{[1
,2
]}

Maffei E. ^{[2
]}

Palumbo A. ^{[1
,2
]}

Malagò R. ^{[1
,3
]}

Alberghina F. ^{[1
]}

Aldrovandi A. ^{[2
]}

Brambilla V. ^{[4
]}

Runza G. ^{[5
]}

La Grutta L. ^{[5
]}

Menozzi A. ^{[2
]}

Vignali L. ^{[2
]}

Casolo G. ^{[6
]}

Midiri M. ^{[5
]}

Mollet N.R. ^{[1
]}

机构：

[1] Dipartimento di Radiologia e Cardiologia, Erasmus Medical Center, Rotterdam

[2] Dipartimento di Radiologia e di Cardiologia, Azienda Ospedaliero-Universitaria di Parma, Parma I-43100, Viale Rustici

[3] Dipartimento di Radiologia, Università degli Studi di Verona, Verona

[4] Unità di Riabilitazione Cardiovascolare, Fondazione Don Gnocchi ONLUS, Parma

[5] DIBIMEL, Sezione di Scienze Radiologiche, Università di Palermo, Palmermo

[6] Dipartimento di Cardiologia, Ospedale Versilia, Lido di Camaiore - Viareggio

来源：

La radiologia medica | 2007年 / 112卷 / 7期

关键词：

64-slice CT; Conventional coronary angiography; Coronary artery disease; CT coronary angiography; Low cardiovascular risk; Multislice computed tomography;

D O I：

10.1007/s11547-007-0198-5

中图分类号：

学科分类号：

摘要：

Purpose. Our aim was to evaluate the diagnostic accuracy of 64-slice computed tomography coronary angiography (MSCT-CA) for detecting significant stenosis (≥50% lumen reduction) in a population of patients at low to intermediate risk. Materials and methods. We studied 72 patients (38 men, 34 women, mean age 53.9±8.0 years) with atypical or typical chest pain and stratified in the low-to intermediate risk category. MSCT-CA (Sensation 64 Cardiac, Siemens, Germany) was performed after IV administration of 100 ml of iodinated contrast material (Iomeprol 400 mgI/ml, Bracco, Italy). Two observers, blinded to the results of conventional coronary angiography (CAG), assessed the MSCT-CA scans in consensus. Diagnostic accuracy for detecting significant stenosis was calculated. Results. CAG demonstrated the absence of significant disease in 70.1% of patients (51/72). No patient was excluded from MSCT-CA. There were 37 significant lesions on 1,098 available coronary segments. Sensitivity, specificity and positive and negative predictive value of MSCT-CA for detecting significant coronary artery on a per-segment basis were 100%, 98.6%, 71.2% and 100%, respectively. All patients with at least one significant lesion were correctly identified by MSCT-CA. MSCT-CA scored 15 false positives on a per-segment base, which affected only marginally the per-p.atient performance (only one false positive). Conclusions. We concluded that 64-slice CT-CA is a diagnostic modality with high sensitivity and negative predictive value in patients at low to intermediate risk. © 2007 Springer-Verlag Italia.

引用

页码：969 / 981

页数：12

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