The Treatment of De Novo Acromegalic Patients with Octreotide-LAR: Efficacy, Tolerability and Cardiovascular Effects

被引：20
作者：
J. Gilbert
M. Ketchen
P. Kane
T. Mason
E. Baister
M. Monaghan
S. Barr
P.E. Harris
机构：
[1] King's College Hospital,Department of Endocrinology
[2] King's College Hospital,Department of Cardiology
[3] Novartis Pharmaceuticals,Department of Endocrinology
[4] King's College Hospital,undefined
[5] King's College Hospital,undefined
来源：
Pituitary | 2003年 / 6卷 / 1期
关键词：
acromegaly; treatment; octreotide-LAR; GH; IGF-I; cardiovascular;
D O I：
10.1023/A:1026273509058
中图分类号：
学科分类号：
摘要：
Aim: Somatostatin analogues are normally used as adjunctive therapy to surgery and radiotherapy in management of acromegaly. We studied the effects of de novo OCT-LAR treatment on growth hormone (GH) suppression, tumour size, cardiovascular function, clinical symptoms, signs and quality of life in 9 newly diagnosed acromegalic patients.
引用
收藏
页码：11 / 18
页数：7
相关论文
共 186 条
[1]  
Wright AD(1970)Mortality in acromegaly Quarterly Journal of Medicine 153 1-16
[2]  
Hill DM(1988)Epidemiology and longterm survival in acromegaly Acta Medicus Scandinavia 233 327-335
[3]  
Lowy C(1999)Impact of patient's age and disease duration on cardiac performance in acromegaly: A radionuclide angiography study J Clin Endocrinol Metab 84 1518-1526
[4]  
Russell-Fraser T.(1998)Echocardiographic evidence for a direct effect of GH/IGF 1 hypersecretion on cardiac mass and function in young acromegalics Clin Endocrinol 49 101-106
[5]  
Bengtsson B(1993)Audit of outcome of treatment in acromegaly Quarterly Journal of Medicine 86 293-299
[6]  
Eden S(1998)Long term mortality after Trans-sphenoidal surgery and adjunctive therapy for acromegaly J Clin Endocrinol Metab 83 3419-3426
[7]  
Ernest I(1993)Acromegaly treatment after 100 years British Medical Journal 307 1505-1506
[8]  
Oden A(1994)Factors determining the long-term outcome of surgery in acromegaly Quarterly Journal of Medicine 87 617-623
[9]  
Sjogren B.(1999)Outcome of trans-sphenoidal surgery for acromegaly and its relationship to surgical experience Clin Endocrinol 50 561-567
[10]  
Colao A(1997)Evidence for the effectiveness of radiotherapy in the treatment of acromegaly J Endocrinol 155 S57-58
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