Effect of Sulfation and Molecular Weight on Anticoagulant Activity of Dextran

被引：0
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作者：
N. N. Drozd
Yu. S. Logvinova
M. A. Torlopov
E. V. Udoratina
机构：
[1] National Research Center for Hematology,Institute of Chemistry, Komi Science Center
[2] Ministry of Health of the Russian Federation,undefined
[3] Ural Division of the Russian Academy of Sciences,undefined
来源：
Bulletin of Experimental Biology and Medicine | 2017年 / 162卷
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摘要：
Sulfation (to 2.8) of dextrans with molecular weight of 150 and 20 kDa was followed by the appearance of anticoagulant activity that increased with decreasing their molecular weight and did not depend on antithrombin, plasma inhibitor of serine proteases of the blood coagulation system. Antithrombin activity of dextran sulfate with a molecular weight of 20 kDa reached 12.6-15.3 U/mg. Dextran sulfates with molecular weights of 20 and 150 kDa did not potentiate ADP-induced human platelet aggregation.
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页码：462 / 465
页数：3
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