Clinical significance of Angiopoietin-1 in Behcet’s disease patients with vascular involvement

被引:0
作者
Iman H. Bassyouni
Mohammed Sharaf
Iman E. Wali
Hossam M. Mansour
机构
[1] Cairo University,Department of Rheumatology and Rehabilitation, Faculty of Medicine, El
[2] Cairo University,Kasr El
[3] Six of October University,Aini Hospital
来源
Heart and Vessels | 2016年 / 31卷
关键词
Angiogenesis; Angiopoietin; Behcet’s disease; Vasculitis;
D O I
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学科分类号
摘要
Behcet’s disease (BD) is a chronic multisystem inflammatory disorder of unclear etiology. Vascular inflammation, endothelial dysfunction and angiogenesis may be in part responsible for the pathogenesis of BD. Angiopoietin-1 (Ang-1) is a recent angiogenic mediator. The aim of the present study was to assess Ang-1 in the plasma of BD patients as well as to analyze its association with clinical, and laboratory parameters of the disease. The present study included 47 BD patients and 30 age- and gender-matched healthy controls. Demographic, clinical, disease activity and severity were prospectively assessed. Plasma Ang-1 levels were measured using enzyme-linked immunosorbent assay. The plasma level of Ang-1 in BD patients was significantly lower than healthy controls (p = 0.005). Plasma Ang-1 level in patients with vascular affection was significantly lower than those without vascular affection (p = 0.045). Levels of Ang-1 showed a significant positive correlation with steroid dose. Patients who received cyclophosphamide or steroids showed a significant increase in plasma Ang-1 level. This was further confirmed by the results of the multivariate analysis. There was no significant association between plasma Ang-1 levels and other clinical manifestations or disease activity and severity. Plasma Ang-1 levels were diminished in our BD patients especially in patients with vascular involvement. Larger studies with further investigations of the precise role of Ang-1 in the pathogenesis of BD are needed and might lead to novel therapies for the clinical management of BD
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页码:918 / 924
页数:6
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