An alternative synthesis of [11C]raclopride for routine use

被引：0
作者：
Kiichi Ishiwata
Shin-ichi Ishii
Michio Senda
机构：
[1] Tokyo Metropolitan Institute of Gerontology,Positron Medical Center
来源：
Annals of Nuclear Medicine | 1999年 / 13卷
关键词：
[; C]raclopride; dopamine D; receptor; PET;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The standard method of [11C]raclopride synthesis requires a large amount of its desmethyl precursor. We prepared [11C]raclopride by methylation of a small amount of desmethyl derivative (0.3–0.5 mg) with [11C]methyl iodide in a DMF solution containing NaH, with a decay-corrected radiochemical yield of 11–14% based on [11C]methyl iodide and with a specific activity of 48 TBq/ mmol for 25 min from EOB. The reaction was reproducible and reliable.
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页码：195 / 197
页数：2
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