The Role of P2Y6 Receptors in the Mechanisms of the Neuroprotective Effect of Citicoline

被引：0
|
作者：
G. Z. Sufianova
A. G. Shapkin
M. S. Khlestkina
L. N. Maslov
A. V. Mukhomedzyanov
N. S. Voronkov
A. A. Sufianov
机构：
[1] Ministry of Health of the Russian Federation,Department of Pharmacology, Tyumen State Medical University
[2] Ministry of Health of the Russian Federation,Federal Center of Neurosurgery
[3] Russian Academy of Sciences,Laboratory of Experimental Cardiology, Cardiology Research Institute, Tomsk National Research Medical Center
[4] Ministry of Health of the Russian Federation (Sechenov University),Department of Neurosurgery, I. M. Sechenov First Moscow State Medical University
来源：
Bulletin of Experimental Biology and Medicine | 2023年 / 175卷
关键词：
citicoline; P; Y; receptor; MRS2578; brain ischemia; neuroprotection;
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学科分类号：
摘要：
Spontaneous bioelectrical activity of the brain and the duration of gasping were recorded in mice during modeling of global strangulation ischemia of the brain against the background of preventive administration of citicoline. The maximum neuroprotective effect of citicoline was observed when it was administered 60 min before the simulation of ischemia and was completely prevented by preliminary administration of a selective P2Y6 receptor antagonist MRS2578. The obtained experimental data attest to the leading role of receptor mechanisms in the implementation of neuroprotective activity of citicoline.
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页码：45 / 48
页数：3
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