Proximicin A, B and C, Novel Aminofuran Antibiotic and Anticancer Compounds Isolated from Marine Strains of the Actinomycete Verrucosispora†

被引：0
|
作者：
Hans-Peter Fiedler
Christina Bruntner
Julia Riedlinger
Alan T Bull
Gjert Knutsen
Michael Goodfellow
Amanda Jones
Luis Maldonado
Wasu Pathom-aree
Winfried Beil
Kathrin Schneider
Simone Keller
Roderich D Sussmuth
机构：
[1] Mikrobiologisches Institut,Department of Biosciences
[2] Universität Tübingen,Department of Biology
[3] University of Kent,undefined
[4] University of Bergen,undefined
[5] School of Biology,undefined
[6] University of Newcastle,undefined
[7] Institut für Pharmakologie,undefined
[8] Medizinische Hochschule Hannover,undefined
[9] Institut für Chemie,undefined
[10] FG Organische Chemie,undefined
[11] Technische Universität Berlin,undefined
来源：
The Journal of Antibiotics | 2008年 / 61卷
关键词：
aminofuran antibiotics; antitumor activity; marine actinomycetes; physico-chemical properties; proximicin A; proximicin B; proximicin C;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A family of three novel aminofuran antibiotics named as proximicins was isolated from the marine Verrucosispora strain MG-37. Proximicin A was detected in parallel in the marine abyssomicin producer “Verrucosispora maris” AB-18-032. The characteristic structural element of proximicins is 4-amino-furan-2-carboxylic acid, a hitherto unknown γ-amino acid. Proximicins show a weak antibacterial activity but a strong cytostatic effect to various human tumor cell lines.
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页码：158 / 163
页数：5
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