Risks and benefits of transfusion for children with severe anemia in Africa

被引：0
作者：
Thomas Brick
Mark J Peters
机构：
[1] Great Ormond Street Hospital NHS Foundation Trust,Paediatric Intensive Care Unit
[2] Institute of Child Health,Respiratory Critical Care and Anaesthesia Unit
[3] University College London,undefined
来源：
BMC Medicine | / 12卷
关键词：
Africa; Physiology; Anemia; Children; Commentary; Infectious disease; Malaria; Transfusion;
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摘要：
Severe anemia contributes significantly to child mortality in sub-Saharan Africa. Blood transfusion is used in emergencies but carries risks. In BMC Medicine, Olupot-Olupot and colleagues report the findings of a phase II trial in children with severe anemia in Eastern Uganda. They provide important early safety and efficacy data supporting large volume whole blood transfusion (30 ml/kg) compared with the World Health Organization recommendation of 20 ml/kg. Large volume transfusions result in more rapid and frequent correction of severe anemia; they can be expected to reduce the risk of transfusions, and help manage the scarce resource of donor blood. However, severe anemia arises from varying combinations of acute, sub-acute and chronic etiologies.
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