Biochemical and Molecular Mechanisms of Liver Damage-Induced by Antidepressant Drugs: an Update Review

Purpose of Review: Antidepressants have effects on liver injury. This review paper has addressed all scientific findings relevant to antidepressant-mediated liver injury since last 5 years. The authors have also discussed about the future scope in this issue. Recent Findings: Usually antidepressants can induce hepatotoxicity to different extent considering the duration of treatment from several days to years. Manifestation of pathophysiochemical and pathological parameter of antidepressant-induced liver injury develops due to adverse reaction of antidepressants. The antidepressants such as duloxetine, milnacipran, venlafaxine, nefazodone, fluoxetine, sertraline, carbamazepine, imipramine, mianserine, and clomipramine showed greater risks of hepatotoxicity. Antidepressant drugs also have some remarkable impact on epidemiological and genetic information. Summary: Liver function test is the most useful tool for detecting antidepressant drug-induced liver injury and early discontinuation of the drug is more responsible action for reducing the risk of injury. Additionally, findings about mechanistic aspect of toxicity and dose dependent study of antidepressant drugs may be a direction to carry out further research. © Springer Science+Business Media, LLC 2017.