Oxytosis/Ferroptosis in Neurodegeneration: the Underlying Role of Master Regulator Glutathione Peroxidase 4 (GPX4)

被引：0
作者：
Nawab John Dar
Urmilla John
Nargis Bano
Sameera Khan
Shahnawaz Ali Bhat
机构：
[1] University of Texas Health San Antonio,School of Medicine
[2] Jiwaji University,School of Studies in Neuroscience
[3] Jiwaji University,School of Studies in Zoology
[4] Aligarh Muslim University,Faculty of Life Sciences, Department of Zoology
来源：
Molecular Neurobiology | 2024年 / 61卷
关键词：
Oxytosis/ferroptosis; Lipid peroxidation; GPX4; Neurodegeneration; Oxidative stress; AD; PD; ALS;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Oxytosis/ferroptosis is an iron-dependent oxidative form of cell death triggered by lethal accumulation of phospholipid hydroperoxides (PLOOHs) in membranes. Failure of the intricate PLOOH repair system is a principle cause of ferroptotic cell death. Glutathione peroxidase 4 (GPX4) is distinctly vital for converting PLOOHs in membranes to non-toxic alcohols. As such, GPX4 is known as the master regulator of oxytosis/ferroptosis. Ferroptosis has been implicated in a number of disorders such as neurodegenerative diseases (amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD), Parkinson’s disease (PD), and Huntington’s disease (HD), etc.), ischemia/reperfusion injury, and kidney degeneration. Reduced function of GPX4 is frequently observed in degenerative disorders. In this study, we examine how diminished GPX4 function may be a critical event in triggering oxytosis/ferroptosis to perpetuate or initiate the neurodegenerative diseases and assess the possible therapeutic importance of oxytosis/ferroptosis in neurodegenerative disorders. These discoveries are important for advancing our understanding of neurodegenerative diseases because oxytosis/ferroptosis may provide a new target to slow the course of the disease.
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页码：1507 / 1526
页数：19
相关论文
共 883 条
[1]  
Stockwell BR(2017)Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease Cell 171 273-285
[2]  
Angeli JPF(2011)Programmed cell death in animal development and disease Cell 147 742-758
[3]  
Bayir H(1995)Apoptosis in the pathogenesis and treatment of disease Science 267 1456-1462
[4]  
Bush AI(2009)Pyroptosis: host cell death and inflammation Nat Rev Microbiol 7 99-109
[5]  
Conrad M(2010)Necroptosis as an alternative form of programmed cell death CurrOpin Cell Biol 22 263-268
[6]  
Dixon SJ(2012)Ferroptosis: an iron-dependent form of nonapoptotic cell death Cell 149 1060-1072
[7]  
Fuchs Y(2014)Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice Nat Cell Biol 16 1180-1191
[8]  
Steller H(2016)Ferroptosis: process and function Cell Death Differ 23 369-379
[9]  
Thompson CB(2016)Ferroptosis: death by lipid peroxidation Trends Cell Biol 26 165-176
[10]  
Bergsbaken T(2017)Iron and thiol redox signaling in cancer: an exquisite balance to escape ferroptosis Free Radic Biol Med 108 610-626
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