Diagnosis of antifungal drug resistance mechanisms in fungal pathogens: Transcriptional gene regulation

被引：3
作者：
Sanglard D. [1 ]
机构：
[1] Institute of Microbiology, University of Lausanne and University Hospital Center, CH-1011 Lausanne
来源：
Current Fungal Infection Reports | 2011年 / 5卷 / 3期
关键词：
Antifungal drug resistance; Aspergillus; Candida; Diagnosis; Multidrug transporters; Mutations;
D O I：
10.1007/s12281-011-0055-9
中图分类号：
学科分类号：
摘要：
Several fungal species can cause mild to severe diseases in humans. Antifungal strategies have been made possible by the development of several drugs with antifungal activity against these pathogenic fungi. Fungi have counteracted antifungal agents in several cases by developing resistance mechanisms. These mechanisms are based on the modifications of drug target genes and on the regulation of drug-resistance genes. Their regulation is controlled by different transcription factors, and recently several mutations in these factors were demonstrated to be responsible for the development of antifungal drug resistance. Given the availability of this genome information, the detection of antifungal resistance could be realized by specific diagnostic tools with DNA-based detection technologies. Here we review the current understanding of transcriptional regulation of drug-resistance genes from several fungal pathogens and prospective diagnostic options. © Springer Science+Business Media, LLC 2011.
引用
收藏
页码：157 / 167
页数：10
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