Streptozotocin increases free fatty acids and decreases phospholipids in rat brain

被引：0

作者：

D. Müller

R. M. Nitsch

R. J. Wurtman

S. Hoyer

机构：

[1] Department of Pathochemistry and General Neurochemistry,

[2] University of Heidelberg,undefined

[3] and,undefined

[4] Center for Molecular Neurobiology,undefined

[5] University of Hamburg,undefined

[6] Federal Republic of Germany,undefined

[7] Department of Brain and Cognitive Sciences,undefined

[8] MIT,undefined

[9] Cambridge,undefined

[10] MA,undefined

[11] U.S.A.,undefined

来源：

Journal of Neural Transmission | 1998年 / 105卷

关键词：

Keywords: Brain lipid metabolism; free fatty acids; phospholipids; streptozotocin; neurodegeneration; animal model.;

D O I：

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中图分类号：

学科分类号：

摘要：

Streptozotocin (STZ) is a diabetogenic drug that disrupts glucose and energy metabolism in brain. To study its effect on brain lipids, tissue concentrations of free fatty acids and phospholipids were measured in the temporal cortex and the hippocampus of adult rats 3 weeks after a single intracerebroventricular (icv) injection of STZ. STZ increased concentrations of palmitic acid and stearic acid in temporal cortex and these of arachidonic acid both in the anterior part of the hippocampus and in CA1. In addition, palmitic acid and stearic acid concentrations were elevated in the anterior hippocampus. In contrast, STZ decreased brain cortex levels of phosphatidylethanolamine and phosphatidylserine. These data show that STZ alters brain lipid metabolism. They suggest that oxidative phospholipid breakdown is accelerated by STZ. These changes may be related to decreased brain glucose utilization and energy formation.

引用

页码：1271 / 1281

页数：10