Rapid Attainment of Steady-State Plasma Drug Concentrations Within Precise Limits in Multicompartment Mammillary Systems

被引：0

作者：

Ben Korman

Les S. Jennings

机构：

[1] Royal Perth Hospital,Department of Anaesthesia

[2] University of Western Australia,Centre for Applied Dynamics and Optimization, Department of Mathematics

来源：

Journal of Pharmacokinetics and Biopharmaceutics | 1999年 / 27卷

关键词：

anesthetic techniques; continuous infusion; pharmacokinetics;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

We have previously described a method of rapidly obtaining a specified steady-state plasma concentration of an intravenous drug within precise limits. However the method is limited to drugs whose disposition may be characterized by an open two-compartment system. In this paper, we illustrate how the method can be extended to drugs whose disposition may be characterized by a mammillary model with any number of compartments. Refinements of our previous technique are also described.

引用

页码：325 / 328

页数：3