Coexistence of three distinct adrenal tumors in the same adrenal gland in a patient with primary aldosteronism and preclinical Cushing's syndrome

被引：19

作者：

Okura T. ^{[1
]}

Miyoshi K.-I. ^{[1
]}

Watanabe S. ^{[1
]}

Kurata M. ^{[1
]}

Irita J. ^{[1
]}

Manabe S. ^{[1
]}

Fukuoka T. ^{[1
]}

Higaki J. ^{[1
]}

Sasano H. ^{[2
]}

机构：

[1] Second Department of Internal Medicine, Ehime University School of Medicine, Toon

[2] Department of Pathology, Tohoku University School of Medicine, Sendai, Miyagi

来源：

Clinical and Experimental Nephrology | 2006年 / 10卷 / 2期

关键词：

Adrenocortical adenoma; Black adenoma; Lipofuscin; Preclinical Cushing's syndrome; Primary aldosteronism;

D O I：

10.1007/s10157-006-0413-z

中图分类号：

学科分类号：

摘要：

A 62-year-old woman was admitted to our hospital because of hypokalemia. Physical examination revealed no signs of excessive adrenocortical steroid production, as are found in Cushing's syndrome. Her plasma renin activity (PRA) was suppressed (0.10ng/ml per h), and her serum aldosterone level was high (30.0ng/dl). PRA was not increased after a renin-releasing test. Her plasma adrenocorticotropic hormone (ACTH) level was low (<5pg/ml), but her serum cortisol level was normal (21.0μg/dl). Administration of 8mg dexamethasone did not suppress her plasma cortisol level. Finally, she was diagnosed with clinical primary aldosteronism associated with preclinical Cushing's syndrome. Magnetic resonance image revealed three sequential nodular masses (each 15mm × 15mm) in the right adrenal gland. A right adrenalectomy was performed by endoscopy. The three removed tumors appeared to have different characteristics. Microscopic examination revealed that the upper and lower tumors were adrenocortical adenomas, and the middle tumor was a black adenoma. Immunohistochemical staining for the enzymes involved in cortisol biosynthesis suggested that the upper tumor secreted aldosterone, whereas either or both of the two other tumors secreted cortisol. Surprisingly, at 33 years of age, she had been diagnosed with Cushing's syndrome, due to a cortisol-producing adrenocortical adenoma, and she had received a left adrenalectomy. Clinically and pathophysiologically, this was a very rare case. © Japanese Society of Nephrology 2006.

引用

页码：127 / 130

页数：3

共 12 条

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