Glomerular filtration rate and prevalence of chronic kidney disease in Wilms’ tumour survivors

被引:0
作者
Joanna Stefanowicz
Mateusz Kosiak
Grzegorz Romanowicz
Radosław Owczuk
Elżbieta Adamkiewicz-Drożyńska
Anna Balcerska
机构
[1] Medical University of Gdansk,Department of Paediatrics, Haematology, Oncology, Endocrinology
[2] Medical University of Gdansk,Department of Family Medicine
[3] Medical University of Gdansk,Department of Nuclear Medicine
[4] Medical University of Gdansk,Department of Anaesthesiology and Intensive Therapy
来源
Pediatric Nephrology | 2011年 / 26卷
关键词
99 Tc-DTPA; eGFR formulas; Cystatin C; CKD; Wilms’ tumour survivors;
D O I
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学科分类号
摘要
Glomerular filtration rate (GFR) was evaluated in 32 Wilms’ tumour survivors (WTs) in a cross-sectional study using 99 Tc-diethylene triamine pentaacetic acid (99 Tc-DTPA) clearance, the Schwartz formula, the new Schwartz equation for chronic kidney disease (CKD), cystatin C serum concentration and the Filler formula. Kidney damage was established by beta-2-microglobulin (B-2-M) and albumin urine excretion, urine sediment and ultrasound examination. Blood pressure was measured. No differences were found between the mean GFR in 99 Tc-DTPA and the new Schwartz equation for CKD (91.8 ± 11.3 vs. 94.3 ± 10.2 ml/min/1.73 m2 [p = 0.55] respectively). No differences were observed between estimated glomerular filtration rate (eGFR) using the Schwartz formula and the Filler formula either (122.3 ± 19.9 vs. 129.8 ± 23.9 ml/min/1.73 m2 [p = 0.28] respectively). Increased urine albumin and B-2-M excretion, which are signs of kidney damage, were found in 7 (22%) and 3 (9.4%) WTs respectively. Ultrasound signs of kidney damage were found in 14 patients (43%). Five patients (15.6%) had more than one sign of kidney damage. Eighteen individuals (56.25%) had CKD stage I (10 with signs of kidney damage; 8 without). Fourteen individuals (43.75%) had CKD stage II (6 with signs of kidney damage; 8 without). The new Schwartz equation for CKD better estimated GFR in comparison to the Schwartz formula and the Filler formula. Furthermore, the WT survivors had signs of kidney damage despite the fact that GFR was not decreased below 90 ml/min/1.73 m2 with 99 Tc- DTPA.
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页码:759 / 766
页数:7
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