Abatacept in the treatment of rheumatoid arthritis

被引：0
作者：
Maya H Buch
Edward M Vital
Paul Emery
机构：
[1] University of Leeds,Academic Unit of Musculoskeletal Disease
来源：
Arthritis Research & Therapy | / 10卷
关键词：
Infliximab; Etanercept; Abatacept; ACR20 Response; Belatacept;
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摘要：
T-cell biology has regained importance in the pathogenesis of rheumatoid arthritis. Despite the significant improvements associated with the introduction of tumor necrosis factor-α blockade, reasonable proportions of failures and suboptimal responses have been reported, necessitating a search for alternative targeted therapies. This has included drug therapy designed to interrupt T-cell activation via the co-stimulation pathway. Abatacept is a recombinant fusion protein that blocks the co-stimulatory signal mediated by the CD28-CD80/86 pathway, which is required for T-cell activation. Several clinical trials have confirmed the safety and efficacy of this drug in the treatment of rheumatoid arthritis. This review summarizes the clinical data supporting this line of treatment and considers the safety and efficacy data from phase II and III trials.
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[1]  
Calin A(1989)Destructive arthritis, rheumatoid factor, and HLA-DR4. Susceptibility versus severity, a case-control study Arthritis Rheum 32 1221-1225
[2]  
Elswood J(1994)The molecular basis of susceptibility to rheumatoid arthritis Adv Immunol 56 389-466
[3]  
Klouda PT(1992)The induction of arthritis in mice by the cartilage proteoglycan aggrecan: roles of CD4 Cell Immunol 144 347-357
[4]  
Winchester R(1989) and CD8 Cell Immunol 121 1-12
[5]  
Banerjee S(1995)T cells J Clin Invest 96 1746-1758
[6]  
Webber C(1975)Collagen arthritis in the rat is initiated by CD4 N Engl J Med 293 517-520
[7]  
Poole AR(2004)T cells and can be amplified by iron Ann Rheum Dis 63 483-488
[8]  
Breedveld FC(1996)Transfer of rheumatoid arthritis into severe combined immunodeficient mice. The pathogenetic implications of T cell populations oligoclonally expanding in the rheumatoid joints Annu Rev Immunol 14 397-440
[9]  
Dynesius-Trentham R(1999)Predominantly T-cell infiltrate in rheumatoid synovial membranes Lancet 354 1932-1939
[10]  
de Sousa M(1997)T cells, fibroblast-like synoviocytes, and granzyme B N Engl J Med 337 141-147
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