Beclin 1: a BH3-only protein that fails to induce apoptosis

被引：0

作者：

P Boya

G Kroemer

机构：

[1] 3D Lab (Development,Department of Cellular and Molecular Physiopathology

[2] Differentiation & Degeneration),undefined

[3] Centro de Investigaciones Biológicas,undefined

[4] CSIC,undefined

[5] Ramiro de Maetzu 9,undefined

[6] INSERM,undefined

[7] U848,undefined

[8] Institut Gustave Roussy,undefined

[9] Université Paris Sud/Paris 11,undefined

[10] Pavillon de Recherche 1,undefined

来源：

Oncogene | 2009年 / 28卷

关键词：

autophagy; apoptosis; Bcl-2, Beclin-1; endoplasmic reticulum; mitochondria;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Beclin 1 has been recently shown to possess a Bcl-2 homology-3 (BH3) domain that mediates its interaction with antiapoptotic multidomain proteins. Unlike other BH3-only proteins, Beclin 1 fails to stimulate apoptosis when it is overexpressed. In this issue of Oncogene, Ciechomska et al. report the intriguing finding that Bcl-2, as it interacts with Beclin 1, does not lose its anti-apoptotic potential. This finding may have far-reaching implications for the comprehension of the cross-talk between apoptosis and autophagy.

引用

页码：2125 / 2127

页数：2

共 48 条

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