Beclin 1: a BH3-only protein that fails to induce apoptosis

被引：0
作者：
P Boya
G Kroemer
机构：
[1] 3D Lab (Development,Department of Cellular and Molecular Physiopathology
[2] Differentiation & Degeneration),undefined
[3] Centro de Investigaciones Biológicas,undefined
[4] CSIC,undefined
[5] Ramiro de Maetzu 9,undefined
[6] INSERM,undefined
[7] U848,undefined
[8] Institut Gustave Roussy,undefined
[9] Université Paris Sud/Paris 11,undefined
[10] Pavillon de Recherche 1,undefined
来源：
Oncogene | 2009年 / 28卷
关键词：
autophagy; apoptosis; Bcl-2, Beclin-1; endoplasmic reticulum; mitochondria;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Beclin 1 has been recently shown to possess a Bcl-2 homology-3 (BH3) domain that mediates its interaction with antiapoptotic multidomain proteins. Unlike other BH3-only proteins, Beclin 1 fails to stimulate apoptosis when it is overexpressed. In this issue of Oncogene, Ciechomska et al. report the intriguing finding that Bcl-2, as it interacts with Beclin 1, does not lose its anti-apoptotic potential. This finding may have far-reaching implications for the comprehension of the cross-talk between apoptosis and autophagy.
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页码：2125 / 2127
页数：2
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