L1 retrotransposition in human neural progenitor cells

被引：0
作者：
Nicole G. Coufal
José L. Garcia-Perez
Grace E. Peng
Gene W. Yeo
Yangling Mu
Michael T. Lovci
Maria Morell
K. Sue O’Shea
John V. Moran
Fred H. Gage
机构：
[1] Laboratory of Genetics,Departments of Human Genetics and Internal Medicine
[2] The Salk Institute for Biological Studies,Department of Cell and Developmental Biology
[3] 10010 North Torrey Pines Road,undefined
[4] La Jolla,undefined
[5] California 92037,undefined
[6] USA ,undefined
[7] 1241 East Catherine Street,undefined
[8] University of Michigan Medical School,undefined
[9] Ann Arbor,undefined
[10] Michigan 48109-5618,undefined
[11] USA,undefined
[12] Andalusian Stem Cell Bank,undefined
[13] Center for Biomedical Research,undefined
[14] Avda Conocimiento s/n,undefined
[15] University of Granada,undefined
[16] 18100,undefined
[17] Spain ,undefined
[18] 109 Zina Pitcher,undefined
[19] University of Michigan Medical School,undefined
[20] Ann Arbor,undefined
[21] Michigan 48109-2200,undefined
[22] USA,undefined
[23] Howard Hughes Medical Institute,undefined
[24] Chevy Chase,undefined
[25] Maryland 20815-6789,undefined
[26] USA ,undefined
[27] Present address: Stem Cell Program,undefined
[28] Department of Cellular and Molecular Medicine,undefined
[29] University of California,undefined
[30] San Diego,undefined
[31] 9500 Gilman Drive,undefined
[32] La Jolla,undefined
[33] California 92093-5004,undefined
[34] USA.,undefined
来源：
Nature | 2009年 / 460卷
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学科分类号：
摘要：
It is known that LINE-1 (long interspersed element-1) retrotransposons can move throughout the genomes of adult rat neural progenitor cells (NPCs) in vitro and in the mouse brain. Now it is shown that NPCs isolated from human fetal brain and derived from human embryonic stem cells also support the retrotransposition of engineered human LINE-1s in vitro. Interestingly, there is an increase in the copy number of endogenous LINE-1s in the hippocampus and elsewhere in adult human brains when compared to the copy number of endogenous LINE-1s in heart or liver genomic DNA from the same individual. This suggests that LINE-1 retrotransposition events may contribute to individual somatic mosaicism and heterogeneity of gene expression in the brain.
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页码：1127 / 1131
页数：4
相关论文
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