A chemical logic for reprogramming to pluripotency

被引：0
作者：
Alejandro De Los Angeles
George Q Daley
机构：
[1] Stem Cell Transplantation Program,Division of Pediatric Hematology/Oncology
[2] Manton Center for Orphan Disease Research,Department of Biological Chemistry and Molecular Pharmacology
[3] Howard Hughes Medical Institute,undefined
[4] Children's Hospital Boston and Dana Farber Cancer Institute,undefined
[5] Harvard Medical School,undefined
[6] Broad Institute,undefined
[7] Harvard Stem Cell Institute,undefined
来源：
Cell Research | 2013年 / 23卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Pluripotency can be experimentally induced from somatic cells by nuclear transfer, fusion with embryonic stem cells, or ectopic transcription factor induction, but attempts to recapitulate this process by chemical means alone have previously failed. In a recent paper published in Science, Hou et al. pursue a rational, albeit laborious approach to identify cocktails of small molecules whose treatment restores pluripotency in adult somatic cells.
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页码：1337 / 1338
页数：1
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