Anti-inflammatory defense mechanisms of Entamoeba histolytica

被引：0
作者：
Raúl Silva-García
Guadalupe Rico-Rosillo
机构：
[1] CMN-Siglo XXI,Unidad de Investigación Médica en Inmunología, Hospital de Pediatría
[2] Av. Universidad 3000 circuito escolar s/n,División de Investigación, Facultad de Medicina UNAM
[3] Col. Copilco,undefined
来源：
Inflammation Research | 2011年 / 60卷
关键词：
In vivo inflammation; Wound healing; Leukocyte migration; Macrophages; NF-κB;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The monocyte locomotion inhibitory factor (MLIF), a heat-stable oligopeptide found in the supernatant fluid of Entamoeba histolytica axenic cultures, may contribute to the delayed inflammation observed in amoebic hepatic abscess. This factor was isolated by ultra-filtration and high powered liquid chromatography, obtaining a primary Met-Gln-Cys-Asn-Ser structure, identified afterwards as the carboxyl-terminal (…Cys-Asn-Ser) active site. The selective anti-inflammatory effects of the pentapeptide have been observed in both in vitro and in vivo models, using a synthetic pentapeptide to maintain the same anti-inflammatory conditions during the experimental assays. Anti-inflammatory effects observed include inhibition of human monocyte locomotion and the respiratory burst in monocytes and neutrophils, increasing expression of anti-inflammatory cytokines and inhibiting expression of the adhesion molecules VLA-4 and VCAM, among others. In this review, we will describe the effects of MLIF detected so far and how it might be used as a therapeutical agent against inflammatory diseases.
引用
收藏
页码：111 / 117
页数：6
相关论文
共 252 条
[51]  
Keller K(2002)IL-12: a key cytokine in immune regulation Dev Biol 250 231-543
[52]  
Chadee RA(2005)Normal human lung fibroblasts differently modulate interleukin-10 and interleukin-12 production by monocytes: implications for an altered immune response in pulmonary chronic inflammation Dev Cell 9 535-162
[53]  
Salata RD(2001)The amebic anti-inflammatory monocyte locomotion inhibitory factor (MLIF) modifies the NF-κB nuclear translocation in human monocytes Mol Cell Endocrinol 180 155-1560
[54]  
Pearson JI(2000)Pituitary actions of ligands of the TGF-beta family: activins and inhibins Mediators Inflamm 9 1551-1103
[55]  
Ravdin RL(2001)Activin A and follistatin: their role in the acute phase reaction and inflammation Curr Pharm Desigs 7 1083-511
[56]  
Guerrant J(2006)The plasmacytoma growth inhibitor restrictin-P is an antagonist of interleukin 6 and interleukin 11. Identification as a stroma-derived activin A Clin Microbiol Rev 13 491-562
[57]  
Brush JI(2003)Activin A regulates the production of mature interleukin-1beta and interleukin-1 receptor antagonist in human monocytic cells Trends Biotechnol 21 556-7
[58]  
Ravdin JA(2002)Activin A: a novel player and inflammatory marker in inflammatory bowel disease? Curr Med Chem 9 96366-9
[59]  
Sullivan GL(1992)The activin-binding protein follistatin regulates autocrine endothelial cell activity and induces angiogenesis J Neurotrauma Suppl 1 1-undefined
[60]  
Mandell M(1996)Expression of activin A is increased in cirrhotic and fibrotic rat livers J Free Rad. Biom Med 20 1-undefined
12345678910