Anti-inflammatory defense mechanisms of Entamoeba histolytica

被引：0
作者：
Raúl Silva-García
Guadalupe Rico-Rosillo
机构：
[1] CMN-Siglo XXI,Unidad de Investigación Médica en Inmunología, Hospital de Pediatría
[2] Av. Universidad 3000 circuito escolar s/n,División de Investigación, Facultad de Medicina UNAM
[3] Col. Copilco,undefined
来源：
Inflammation Research | 2011年 / 60卷
关键词：
In vivo inflammation; Wound healing; Leukocyte migration; Macrophages; NF-κB;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The monocyte locomotion inhibitory factor (MLIF), a heat-stable oligopeptide found in the supernatant fluid of Entamoeba histolytica axenic cultures, may contribute to the delayed inflammation observed in amoebic hepatic abscess. This factor was isolated by ultra-filtration and high powered liquid chromatography, obtaining a primary Met-Gln-Cys-Asn-Ser structure, identified afterwards as the carboxyl-terminal (…Cys-Asn-Ser) active site. The selective anti-inflammatory effects of the pentapeptide have been observed in both in vitro and in vivo models, using a synthetic pentapeptide to maintain the same anti-inflammatory conditions during the experimental assays. Anti-inflammatory effects observed include inhibition of human monocyte locomotion and the respiratory burst in monocytes and neutrophils, increasing expression of anti-inflammatory cytokines and inhibiting expression of the adhesion molecules VLA-4 and VCAM, among others. In this review, we will describe the effects of MLIF detected so far and how it might be used as a therapeutical agent against inflammatory diseases.
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页码：111 / 117
页数：6
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