SpikeTides™—proteotypic peptides for large-scale MS-based proteomics

Targeted proteomics, as an efficient and sensitive technology for protein identification and quantification, is dependent on the availability of custom peptides for assay development and absolute quantification. For absolute protein quantification the peptides must be heavily labeled and quantified. Current workflows rely on peptides that are prepared by labor-intensive resin-based peptide synthesis. The result is a high price per peptide, thus prohibiting large-scale projects.