Expression of 5-HT2A and 5-HT1B receptor mRNA in blood vessels

被引:0
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作者
Shiro Kato
Hideo Kumamoto
Masahiko Hirano
Hideo Akiyama
Noboru Kaneko
机构
[1] Dokkyo University School of Medicine,The First Department of Internal Medicine
[2] Tochigi Prefecture,Biological Sciences
[3] Tokyo Tanabe Pharmaceutical Company,undefined
[4] Toray Research Center Inc.,undefined
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关键词
5-hydroxytryptamine (5-HT) receptor subtype; 5-HT1B; 5-HT2A; quantitative reverse transcription-polymerase chain reaction (RT-PCR); artery; vein;
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摘要
Expression of two subtypes of 5-hydroxytryptamine (5-HT) receptors, 5-HT1B and 5-HT2A, was investigated in normal rat arteries (abdominal aorta) and veins (inferior vena cava) by the quantitative reverse transcription-polymerase chain reaction (RT-PCR). The arterial 5-HT2A receptor mRNA level in artery was 25-fold (p < 0.01) higher than the venous level, and the arterial 5-HT1B receptor mRNA level was at least 7000-fold (p < 0.005) higher the venous level.
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页码:57 / 62
页数:5
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