Regulation of angiogenesis by a non-canonical Wnt–Flt1 pathway in myeloid cells

被引：0

作者：

James A. Stefater III

Ian Lewkowich

Sujata Rao

Giovanni Mariggi

April C. Carpenter

Adam R. Burr

Jieqing Fan

Rieko Ajima

Jeffery D. Molkentin

Bart O. Williams

Marsha Wills-Karp

Jeffrey W. Pollard

Terry Yamaguchi

Napoleone Ferrara

Holger Gerhardt

Richard A. Lang

机构：

[1] The Visual Systems Group,Divisions of Pediatric Ophthalmology and Developmental Biology

[2] Cincinnati Children’s Hospital Medical Center,Department of Ophthalmology

[3] Cincinnati,Division of Immunobiology

[4] Ohio 45229,Division of Molecular Cardiovascular Biology

[5] USA,undefined

[6] University of Cincinnati,undefined

[7] Cincinnati,undefined

[8] Ohio 45229,undefined

[9] USA,undefined

[10] Cincinnati Children’s Hospital Medical Center,undefined

[11] Cincinnati,undefined

[12] Ohio 45229,undefined

[13] USA,undefined

[14] Vascular Biology Laboratory,undefined

[15] London Research Institute,undefined

[16] Cancer Research UK,undefined

[17] London WC2 3PX,undefined

[18] UK ,undefined

[19] Cincinnati Children’s Hospital Medical Center,undefined

[20] University of Cincinnati,undefined

[21] Cancer and Developmental Biology Laboratory,undefined

[22] National Cancer Institute,undefined

[23] Frederick,undefined

[24] Maryland 21701,undefined

[25] USA ,undefined

[26] Howard Hughes Medical Institute,undefined

[27] Cincinnati Children’s Hospital Medical Center,undefined

[28] University of Cincinnati,undefined

[29] Center for Skeletal Disease Research,undefined

[30] Van Andel Research Institute,undefined

[31] 333 Bostwick NE,undefined

[32] Grand Rapids,undefined

[33] Michigan 49503,undefined

[34] USA ,undefined

[35] Albert Einstein College of Medicine of Yeshiva University,undefined

[36] Jack and Pearl Resnick Campus,undefined

[37] 1300 Morris Park Avenue,undefined

[38] Bronx,undefined

[39] New York 10461,undefined

[40] USA ,undefined

[41] Genentech Inc.,undefined

[42] 1 DNA Way,undefined

[43] South San Francisco,undefined

[44] California 94080,undefined

[45] USA ,undefined

[46] Consultant Group Leader,undefined

[47] Vascular Patterning Laboratory,undefined

[48] Vesalius Research Center,undefined

[49] VIB,undefined

[50] Campus Gasthuisberg,undefined

来源：

Nature | 2011年 / 474卷

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摘要：

Richard Lang and colleagues identify a mechanism by which myeloid cells regulate the pattern of blood-vessel branching in the post-natal retina. They show that macrophages inhibit branching by secreting Wnt ligands that use a non-canonical pathway to induce secretion of the VEGF inhibitory receptor Flt1.

引用

页码：511 / 515

页数：4