Maternal positive mental health during pregnancy impacts the hippocampus and functional brain networks in children

被引：0

作者：

Qiu, Anqi ^{[1
,2
,3
,4
,5
]}

Shen, Chenye ^{[1
]}

Lopez-Vicente, Monica ^{[6
,7
]}

Szekely, Eszter ^{[8
,9
]}

Chong, Yap-Seng ^{[10
]}

White, Tonya ^{[6
,11
,12
]}

Wazana, Ashley ^{[8
,9
]}

机构：

[1] Hong Kong Polytech Univ, Dept Hlth Technol & Informat, Hong Kong, Peoples R China

[2] Natl Univ Singapore Suzhou Res Inst, Suzhou 215000, Jiangsu, Peoples R China

[3] Natl Univ Singapore, N1 Inst Hlth, Singapore, Singapore

[4] Natl Univ Singapore, Dept Biomed Engn, Singapore, Singapore

[5] Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD 21218 USA

[6] Univ Med Ctr, Erasmus MC, Dept Child & Adolescent Psychiat & Psychol, Rotterdam, Netherlands

[7] Univ Med Ctr, Erasmus MC, Generat R Study Grp, Rotterdam, Netherlands

[8] McGill Univ, Fac Med & Hlth Sci, Montreal, PQ, Canada

[9] Jewish Gen Hosp, Lady Davis Inst Med Res, Montreal, PQ, Canada

[10] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Obstet & Gynaecol, Singapore, Singapore

[11] Univ Med Ctr, Dept Radiol & Nucl Med, Erasmus MC, Rotterdam, Netherlands

[12] Natl Inst Mental Hlth, Sect Social & Cognit Dev Neurosci, Bethesda, MD USA

来源：

NATURE MENTAL HEALTH | 2024年 / 2卷 / 03期

基金：

新加坡国家研究基金会; 英国医学研究理事会; 加拿大健康研究院;

关键词：

DEPRESSIVE SYMPTOMS; CONNECTIVITY; AMYGDALA; HISTORY; STRESS; ASSOCIATION; SENSITIVITY; CORTISOL; BEHAVIOR; VOLUMES;

D O I：

10.1038/s44220-024-00202-8

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Positive mental health is an essential component of overall health and well-being. However, research in this area has been relatively neglected. This study used a longitudinal dataset to investigate the impact of maternal positive emotions during pregnancy on brain structure and function in 7.5-year-old children (n = 381). A positive maternal mental health measure, including positive affect and emotional well-being during pregnancy, was developed through confirmatory factor analysis of questionnaires administered at 26-28 weeks. The study found that girls born to mothers who reported greater positive mental health during pregnancy showed larger bilateral hippocampi. Furthermore, children of mothers with greater positive mental health exhibited altered functional connectivity of several networks, including default mode, salience, executive control, amygdala and thalamo-hippocampal networks. These findings extend the study of maternal mental health beyond maternal psychopathology, suggesting the importance of promoting positive maternal mental health during pregnancy as a potential protective factor for offspring brain development.

引用

页码：320 / 327

页数：12

共 54 条

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