Synthesis of New Sulfonamide Inhibitors of Carbonic Anhydrase

被引：0
作者：
O. Arslan
Ü. Çakir
H. I. Uğraş
机构：
[1] Balikesir University,Faculty of Science and Art, Department of Chemistry
来源：
Biochemistry (Moscow) | 2002年 / 67卷
关键词：
inhibition; carbonic anhydrase; glaucoma; sulfonamides;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Four different derivatives of aromatic sulfonamides have been synthesized: 1,2-bis[(4-sulfonamidobenzamide)ethoxy]ethane (SBAM), 1,2-bis[(4-sulfonamidobenzoate)ethoxy]ethane, 1,2-bis[(2,4-dichloro-5-sulfonamidobenzamide)ethoxy]ethane, and 1,2-bis[(2,4-dichloro-5-sulfonamidobenzoate)ethoxy]ethane. SBAM is a most potent inhibitor on ciliary epithelium carbonic anhydrase and is approximately 13 times more active against carbonic anhydrase isoform II than against isoform I.
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页码：1055 / 1057
页数：2
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