Targeting DNA repair and the cell cycle in glioblastoma

被引：0

作者：

Brian M. Alexander

Nancy Pinnell

Patrick Y. Wen

Alan D’Andrea

机构：

[1] Dana-Farber/Brigham and Women’s Cancer Center,Department of Radiation Oncology

[2] Harvard Medical School,Department of Neurology

[3] Dana-Farber/Brigham and Women’s Cancer Center,undefined

[4] Harvard Medical School,undefined

来源：

Journal of Neuro-Oncology | 2012年 / 107卷

关键词：

DNA repair; Cell cycle; Glioblastoma;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Glioblastoma is a disease with poor outcomes despite standard therapy. Specific targeting of the DNA damage response is a strategy that is becoming increasingly employed in oncology and has intriguing potential for improving outcomes in glioblastoma. DNA damage targeting has implications for improving current therapy as well as the potential to leverage inherent differences in glioblastoma cells to widen the therapeutic window.

引用

页码：463 / 477

页数：14

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