HOTAIR: a potential metastatic, drug-resistant and prognostic regulator of breast cancer

被引：0
作者：
Ganji Seeta Rama Raju
Eluri Pavitra
Sai Samyuktha Bandaru
Ganji Lakshmi Varaprasad
Ganji Purnachandra Nagaraju
Rama Rao Malla
Yun Suk Huh
Young-Kyu Han
机构：
[1] Dongguk University–Seoul,Department of Energy and Materials Engineering
[2] NanoBio High-Tech Materials Research Center,School of Medicine, Division of Hematology and Oncology
[3] Biological Sciences and Bioengineering,Cancer Biology Laboratory, Department of Biochemistry and Bioinformatics
[4] Inha University,undefined
[5] Baton Rouge General Hospital,undefined
[6] University of Alabama,undefined
[7] GIS,undefined
[8] GITAM (Deemed to be University),undefined
来源：
Molecular Cancer | / 22卷
关键词：
Breast cancer; Drug resistance; HOTAIR; Metastasis; Prognosis;
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摘要：
HOX transcript antisense intergenic RNA (HOTAIR) is an oncogenic non-coding RNA whose expression is strongly correlated with the tumor grade and prognosis of a variety of carcinomas including breast cancer (BC). HOTAIR regulates various target genes via sponging and epigenetic mechanisms and controls various oncogenic cellular and signaling mechanisms including metastasis and drug resistance. In BC cells, HOTAIR expression is regulated by a variety of transcriptional and epigenetic mechanisms. In this review, we describe the regulatory mechanisms that govern HOTAIR expression during cancer development and explore how HOTAIR drives BC development, metastasis, and drug resistance. In the final section of this review, we focus on the role of HOTAIR in BC management, therapeutic treatment, and prognosis, highlighting its potential therapeutic applications.
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