Serum Resistin Levels May Contribute to an Increased Risk of Acute Cerebral Infarction

被引：0
作者：
Xiao-Liu Dong
Shi-Jun Xu
Li Zhang
Xiu-Qing Zhang
Ting Liu
Qiu-Yan Gao
Qing-Qiang Qian
Bao-Liang Sun
Ming-Feng Yang
机构：
[1] Tangshan People’s Hospital,Department of Neurology
[2] Tangshan People’s Hospital,Department of Neurosurgery
[3] Tangshan People’s Hospital,Department of Ultrasonic Medicine
[4] Affiliated Tangshan Gongren Hospital of North China University of Science and Technology,Department of Neurology
[5] Taishan Medical University,Key Lab of Cerebral Microcirculation in Universities of Shandong
来源：
Molecular Neurobiology | 2017年 / 54卷
关键词：
Resistin; Acute cerebral infarction; Acute stroke; Acute cerebrovascular disease; Found in inflammatory zone 3; Adipocyte-specific secretory factor;
D O I：
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中图分类号：
学科分类号：
摘要：
The objective of this study was to investigate the association between serum resistin levels and acute cerebral infarction (ACI). PubMed, SpringerLink, Wiley, EBSCO, Ovid, Web of Science, Wanfang, China National Knowledge Infrastructure, and VIP databases (last updated search in October 2014) were exhaustively searched, and data from the eligible studies were extracted and analyzed to assess the association between serum resistin levels and ACI. STATA software (version 12.0, Stata Corporation, College Station, TX, USA) was utilized for data analysis. Ten studies including 1829 ACI patients and 1557 healthy controls were eligible for inclusion in the meta-analysis. Our major result revealed that ACI patients exhibited higher serum resistin levels compared with healthy controls. Asubgroup analysis based on ethnicity showed a significant association between serum resistin levels and ACI in Asians, but surprisingly not in Caucasians. The results of our meta-analysis suggest that serum resistin levels are associated with an increased risk of ACI.
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页码：1919 / 1926
页数：7
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[11]  
Wang Y(2010)Resistin and visfatin: regulators of insulin sensitivity, inflammation and immunity Endocr Regul 44 25-36
[12]  
Li H(2011)Serum resistin level: as a predictor of atrial fibrillation after coronary artery bypass graft surgery Coron Artery Dis 22 484-490
[13]  
Shi D(2011)Human resistin: found in translation from mouse to man Trends Endocrinol Metab 22 259-265
[14]  
Xia T(2011)Resistin induces monocyte-endothelial cell adhesion by increasing ICAM-1 and VCAM-1 expression in endothelial cells via p38 MAPK-dependent pathway J Cell Physiol 226 2181-2188
[15]  
Feng H(2012)Adipocytokines and ischemic stroke: differential associations between stroke subtypes J Neurol Sci 312 117-122
[16]  
Bennett DA(2011)Inflammatory induction of human resistin causes insulin resistance in endotoxemic mice Diabetes 60 775-783
[17]  
Krishnamurthi RV(2011)Resistin, but not adiponectin and leptin, is associated with the risk of ischemic stroke among postmenopausal women: results from the Women’s Health Initiative Stroke 42 1813-1820
[18]  
Barker-Collo S(2014)Resistin as a biomarker linking obesity and inflammation to cancer: potential clinical perspectives Biomark Med 8 107-118
[19]  
Kernan WN(2014)Resistin increases platelet P-selectin levels via p38 MAPK signal pathway Diab Vasc Dis Res 11 121-124
[20]  
Ovbiagele B(2011)Serum resistin in acute myocardial infarction patients with and without diabetes mellitus Postgrad Med J 87 463-467
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