Synthesis and evaluation of anti-proliferative activity of 1,4-disubstituted phthalazines

被引：0
作者：
Khaled A. M. Abouzid
Nadia A. Khalil
Eman M. Ahmed
机构：
[1] Ain Shams University,Pharmaceutical Chemistry Department, Faculty of Pharmacy
[2] Cairo University,Organic Chemistry Department, Faculty of Pharmacy
来源：
Medicinal Chemistry Research | 2012年 / 21卷
关键词：
Breast cancer; Anti-proliferative activity; Phthalazine; Phthalazinone;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A series of new phthalazine derivatives 3a–i and 4a–c were synthesized via the reaction of 1-chlorophthalazine derivative 2 with either N-substituted-piperazines, primary or their secondary amines. The structure of the synthesized, new compounds were characterized by spectral data. The anti-proliferative activity on human breast cancer cell line MCF-7 of the synthesized compounds was determined. The results showed that six of the test compounds (3a, 3g, 3i, and 4a–c) displayed potent cytotoxic activity ranging from 1.4 to 2.3 μmol.
引用
收藏
页码：3288 / 3293
页数：5
相关论文
共 50 条
[41]   Synthesis of new benzo[f]chromene-based heterocycles targeting anti-proliferative activity [J].
Abu El-Azm, Fatma S. M. ;
El-Shahawi, Manal M. ;
Elgubbi, Amna S. ;
Madkour, Hassan M. F. .
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY, 2021, 18 (05) :1081-1092
[42]   Synthesis, anti-proliferative activity, computational studies of tetrazole cellulose utilizing different homogenous catalyst [J].
Dacrory, Sawsan ;
Fahim, Asmaa M. .
CARBOHYDRATE POLYMERS, 2020, 229
[43]   Synthesis of new benzo[f]chromene-based heterocycles targeting anti-proliferative activity [J].
Fatma S. M. Abu El-Azm ;
Manal M. El-Shahawi ;
Amna S. Elgubbi ;
Hassan M. F. Madkour .
Journal of the Iranian Chemical Society, 2021, 18 :1081-1092
[44]   Design, synthesis and evaluation of anti-proliferative activity of 2-ary- l-4-aminoquinazoline derivatives as EGFR inhibitors [J].
Zhou, Zhihui ;
He, Jie ;
Yang, Feiyi ;
Pan, Qingshan ;
Yang, Zunhua ;
Zheng, Pengwu ;
Xu, Shan ;
Zhu, Wufu .
BIOORGANIC CHEMISTRY, 2021, 112
[45]   One-pot synthesis and anti-proliferative activity of hindered 5-amino-1-alkylimidazole-4-carboxamides [J].
Zhang, Yamei ;
Yang, Zijuan ;
Xie, Yong ;
Wang, Yeming .
TETRAHEDRON LETTERS, 2025, 159
[46]   Foodomics evaluation of the anti-proliferative potential of Passiflora mollissima seeds [J].
Ballesteros-Vivas, Diego ;
Alvarez-Rivera, Gerardo ;
Leon, Carlos ;
Johanna Morantes, Sandra ;
Ibanez, Elena ;
Parada-Alfonso, Fabian ;
Cifuentes, Alejandro ;
Valdes, Alberto .
FOOD RESEARCH INTERNATIONAL, 2020, 130
[47]   Synthesis and Anti-proliferative Activity of 4H-Chromone Based Phenylhydrazones, Pyrazolecarboxylates and Pyrazolylmethanones [J].
Rayala, Nageswara Rao ;
Kommera, Rajkumar ;
Cherupally, Dayakar ;
Thampunuri, Ramalinga Murthy ;
Shasi, V. Kalivendi ;
Bhimapaka, China Raju .
ACTA CHIMICA SLOVENICA, 2018, 65 (01) :34-49
[48]   Design, synthesis and potential anti-proliferative activity of some novel 4-aminoquinoline derivatives [J].
Ghorab, Mostafa M. ;
Al-Said, Mansour S. ;
Arafa, Reem K. .
ACTA PHARMACEUTICA, 2014, 64 (03) :285-297
[49]   Design synthesis and anti-proliferative activity of some new coumarin substituted hydrazide–hydrazone derivatives [J].
Nongnaphat Duangdee ;
Wiratchanee Mahavorasirikul ;
Saisuree Prateeptongkum .
Journal of Chemical Sciences, 2020, 132
[50]   Design, synthesis and in vitro anti-proliferative activity of 4,6-quinazolinediamines as potent EGFR-TK inhibitors [J].
Mowafy, Samar ;
Farag, Nahla A. ;
Abouzid, Khaled A. M. .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 61 :132-145
12345